Castelli M, Romano P, Atlante G, Pozzi M, Ferrini U
Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy.
Int J Biol Markers. 1987 Sep-Dec;2(3):187-90. doi: 10.1177/172460088700200310.
Serum levels of the immunosuppressive acidic protein (IAP) and CA-125 were measured in 45 patients with ovarian tumors (30 malignant and 15 benign) before surgery. Concentrations of both markers were slightly increased in benign forms but still within the upper limit for controls. The sensitivity of IAP in detecting ovarian cancer was higher than CA-125 (83.4% versus 76.7%). Five false negatives were observed in IAP assay and seven for CA-125. Parallel determination of both markers, however, improved the diagnostic accuracy up to 90.0% of the total malignant cases. Combined measurements of circulating IAP and CA-125 are therefore recommended in the detection of ovarian cancers.
在45例卵巢肿瘤患者（30例恶性肿瘤和15例良性肿瘤）手术前检测其血清免疫抑制酸性蛋白（IAP）和CA - 125水平。在良性肿瘤中，这两种标志物的浓度略有升高，但仍在对照组上限范围内。IAP检测卵巢癌的敏感性高于CA - 125（83.4%对76.7%）。IAP检测中有5例假阴性，CA - 125检测中有7例假阴性。然而，同时检测这两种标志物可将诊断准确率提高至所有恶性病例的90.0%。因此，建议联合检测循环中的IAP和CA - 125用于卵巢癌的检测。
