School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China; College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.
School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China; College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.
Ultrason Sonochem. 2021 Dec;80:105843. doi: 10.1016/j.ultsonch.2021.105843. Epub 2021 Nov 23.
In this paper, the bubble-cell model is presented. The effects of the spacing between the bubble population and the cell, the radius of the bubble and the bubble medium on the degree of cell deformation were investigated by solving the Helmholtz equation and the equilibrium of motion equation using COMSOL Multiphysis@ software. The ultrasonic transducer is applied in a round bottom flask with the bubble-cell model on the side of the ultrasonic transducer. When the distance between the bubble cluster and the cell gradually increases, the extent of deformation of the cell is reflected as first increasing and then decreasing, reaching the maximum deformation at D = 2. When the radius of the bubble is changed, there is a "constant frequency" at low frequency ultrasound in any distance case, at which the cell deformation will be violent. However, when the bubble medium is changed, there is no significant change in the degree of deformation of the cells. In other words, changes in the structure of the bubble-cell model affect the degree of cell deformation, but without structural changes, the degree of cell deformation changes very little.
本文提出了气泡-细胞模型。通过求解 COMSOL Multiphysics@ 软件中的亥姆霍兹方程和运动平衡方程，研究了气泡群与细胞之间的间距、气泡半径和气泡介质对细胞变形程度的影响。超声换能器应用于一个圆底瓶中，气泡-细胞模型位于超声换能器的一侧。当气泡簇与细胞之间的距离逐渐增加时，细胞的变形程度先增加后减小，在 D=2 时达到最大变形。当气泡半径发生变化时，在任何距离情况下的低频超声中都存在一个“恒定频率”，在该频率下细胞变形会很剧烈。然而，当气泡介质发生变化时，细胞的变形程度没有明显变化。换句话说，气泡-细胞模型的结构变化会影响细胞的变形程度，但在没有结构变化的情况下，细胞的变形程度变化很小。
