Das Anthony V, Pillutla Lalitha N, Chaurasia Sunita
Department of eyeSmart EMR and AEye, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2021 Dec;69(12):3488-3493. doi: 10.4103/ijo.IJO_553_21.
The aim of this study was to describe the clinical profile and demographic distribution of pellucid marginal corneal degeneration (PMD) in patients presenting to a multitier ophthalmology hospital network in India.
This cross-sectional hospital-based study included 2,470,793 new patients presenting between September 2012 and September 2020 (~8 years period). Patients with a clinical diagnosis of PMD in at least one eye were included as cases. The data were collected using an electronic medical record system.
Overall, 559 (0.02%) new patients were diagnosed with PMD. The prevalence rates were 0.004% in children (age <16 years) and 0.03% in adults. The majority of patients were males (70.13%) with the bilateral affliction (77.1%). The mean age of the patients was 37.91 ± 13.19 years. The majority (30.23%) of the patients were between 31 and 40 years of age. A significant number of patients were from higher socioeconomic status (93.74%) and from the urban region (45.08%). Of the 990 eyes, the most common clinical signs were ectasia/thinning (58.99%), corneal scar (17.47%), and corneal hydrops (1.01%). The majority of the eyes (87.97%) were managed with either spectacles or contact lenses. Among those who had surgical intervention, collagen cross-linking was the most performed procedure (5.25%) followed by cataract surgery (4.14%).
PMD is a rare disease affecting patients seeking eye care in India. It commonly affects adult males and is bilateral in nature. The disease progression is slow and usually occurs beyond 3 years. Conservative management is more common than surgical intervention.
本研究旨在描述在印度一家多层眼科医院网络就诊的患者中透明边缘角膜变性（PMD）的临床特征和人口统计学分布。
这项基于医院的横断面研究纳入了2012年9月至2020年9月（约8年期间）就诊的2470793名新患者。至少一只眼睛有PMD临床诊断的患者被纳入病例组。数据通过电子病历系统收集。
总体而言，559名（0.02%）新患者被诊断为PMD。儿童（年龄<16岁）患病率为0.004%，成人患病率为0.03%。大多数患者为男性（70.13%），双侧患病（77.1%）。患者的平均年龄为37.91±13.19岁。大多数（30.23%）患者年龄在31至40岁之间。相当数量的患者来自较高社会经济地位（93.74%）和城市地区（45.08%）。在990只眼中，最常见的临床体征是扩张/变薄（58.99%）、角膜瘢痕（17.47%）和角膜水肿（1.01%）。大多数眼睛（87.97%）通过眼镜或隐形眼镜进行处理。在接受手术干预的患者中，胶原交联是最常进行的手术（5.25%），其次是白内障手术（4.14%）。
PMD是一种罕见疾病，影响在印度寻求眼科护理的患者。它通常影响成年男性，且本质上是双侧性的。疾病进展缓慢，通常在3年后发生。保守治疗比手术干预更常见。
