Department of eyeSmart EMR and AEye, L V Prasad Eye Institute, Hyderabad, Telangana, India, , Hyderabad.
Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2021 Dec;69(12):3482-3486. doi: 10.4103/ijo.IJO_609_21.
To describe the clinical profile and demographic distribution of Terrien's marginal degeneration (TMD) in patients presenting to a multitier ophthalmology hospital network in India.
This cross-sectional hospital-based study included 2,470,793 new patients presenting between September 2012 and September 2020 (~8 years period). Patients with a clinical diagnosis of TMD in at least one eye were included as cases. The data were collected using an electronic medical record system.
Overall, 184 (0.007%) new patients were diagnosed. Over half of patients were males (56.52%) with bilateral affliction (54.89%). The mean age of the patients was 38.63 ± 16.75 years. Majority (28.26%) of the patients were between 21 and 30 years of age bracket. The number of patients were from rural and urban districts were comparable (41.85% vs. 48.37%). The most common clinical signs were ectasia/thinning (50.53%), corneal scar (44.21%), and prominent nerves (5.26%). Associated ocular comorbidities included vernal keratoconjunctivitis in 6 (2.11%) eyes, meibomitis in 6 (9.7%) eyes, squamous blepharitis in 2 (3.2%) eyes, dry eye in 2 (3.2%) eyes, cataract in 46 (74.2%) eyes, and glaucoma in 6 (9.7%) eyes. Most of the eyes had mild or no visual impairment (43.86%). Two (0.7%) eyes had spontaneous perforation patients. None of patients had hydrops in the years of follow-up. Keratoplasty was performed in 3.86%.
TMD is a rare disease affecting patients seeking eye care at the ophthalmology network. It commonly affects adult males and is predominantly bilateral. The disease progression is slow, and risk of spontaneous perforation was low. At initial presentation, visual impairment was mild to moderate in majority and the most common surgical intervention was cataract surgery during the study period.
描述特伦氏边缘变性（TMD）在印度一家多层次眼科医院网络就诊患者的临床特征和人口分布。
这是一项横断面医院病例研究，纳入了 2470793 名 2012 年 9 月至 2020 年 9 月（约 8 年期间）新就诊的患者。至少一只眼临床诊断为 TMD 的患者被纳入病例。数据使用电子病历系统收集。
总体而言，184 名（0.007%）新患者被诊断为 TMD。超过一半的患者为男性（56.52%），双眼受累（54.89%）。患者的平均年龄为 38.63 ± 16.75 岁。大多数（28.26%）患者年龄在 21-30 岁之间。来自农村和城市地区的患者人数相当（41.85% vs. 48.37%）。最常见的临床体征包括扩张/变薄（50.53%）、角膜瘢痕（44.21%）和突出的神经（5.26%）。相关的眼部合并症包括 vernal 角结膜炎 6 只眼（2.11%）、睑板腺炎 6 只眼（9.7%）、鳞状睑缘炎 2 只眼（3.2%）、干眼症 2 只眼（3.2%）、白内障 46 只眼（74.2%）和青光眼 6 只眼（9.7%）。大多数患者视力轻度或不受影响（43.86%）。2 只眼（0.7%）发生自发性穿孔。在随访期间，无患者出现水肿。行角膜移植术 3.86%。
TMD 是一种罕见疾病，影响在眼科网络寻求眼部护理的患者。它通常影响成年男性，主要为双眼受累。疾病进展缓慢，自发性穿孔的风险较低。在初次就诊时，大多数患者的视力损害为轻度至中度，在研究期间最常见的手术干预是白内障手术。
