Antezana Pablo Edmundo, Municoy Sofia, Pérez Claudio Javier, Desimone Martin Federico
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica, Junín 956, Buenos Aires 1113, Argentina.
Grupo Ciencia y Tecnología de Polímeros, Instituto de Investigaciones en Ciencia y Tecnología de Materiales (INTEMA), Universidad Nacional de Mar del Plata, Juan B. Justo 4302, Mar del Plata 7600, Argentina.
Antibiotics (Basel). 2021 Nov 20;10(11):1420. doi: 10.3390/antibiotics10111420.
Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.
伤口是一个重大的医疗保健问题，尤其是在医院相关感染中，这类感染常常涉及多重耐药菌株。如今，负载治疗性分子的生物材料在伤口愈合和感染预防中发挥着积极作用。在这项工作中，描述了负载银纳米颗粒和油提取物的胶原蛋白水凝胶的研制情况。银纳米颗粒的存在赋予了这种生物材料一些有趣的特性，比如改善了机械性能或抗胶原酶降解能力，但最重要的是其持久的抗菌效果。油以其抗炎和止痛作用而闻名，具有抗氧化活性，并成功改善了生物相容性，还增强了纳米复合材料的抗菌活性。总之，这些结果表明，这种新型纳米复合生物材料是伤口感染和伤口愈合常规治疗方法的一个有前景的替代方案。
