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运动员骨骼肌能量代谢调控的候选基因。

Candidate Genes of Regulation of Skeletal Muscle Energy Metabolism in Athletes.

机构信息

The Research Institute of Olympic Sports, Ural State University of Physical Culture, 454091 Chelyabinsk, Russia.

Department of Hand Surgery with Microsurgical Equipment, Vreden National Medical Research Center of Traumatology and Orthopedics, 195427 St. Petersburg, Russia.

出版信息

Genes (Basel). 2021 Oct 23;12(11):1682. doi: 10.3390/genes12111682.

DOI:10.3390/genes12111682
PMID:34828287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8625318/
Abstract

All biological processes associated with high sports performance, including energy metabolism, are influenced by genetics. DNA sequence variations in such genes, single nucleotide variants (SNVs), could confer genetic advantages that can be exploited to achieve optimal athletic performance. Ignorance of these features can create genetic "barriers" that prevent professional athletes from pursuing a career in sports. Predictive Genomic DNA Profiling reveals single nucleotide variations (SNV) that may be associated with better suitability for endurance, strength and speed sports. (1) Background: To conduct a research on candidate genes associated with regulation of skeletal muscle energy metabolism among athletes. (2) Methods: We have searched for articles in SCOPUS, Web of Science, Google Scholar, Clinical keys, PubMed, e-LIBRARY databases for the period of 2010-2020 using keywords and keywords combinations; (4) Conclusions: Identification of genetic markers associated with the regulation of energy metabolism in skeletal muscles can help sports physicians and coaches develop personalized strategies for selecting children, teenagers and young adults for endurance, strength and speed sports (such as jogging, middle or long distance runs). However, the multifactorial aspect of sport performances, including impact of genetics, epigenetics, environment (training and etc.), is important for personalized strategies for selecting of athletes. This approach could improve sports performance and reduce the risk of sports injuries to the musculoskeletal system.

摘要

所有与高运动表现相关的生物过程，包括能量代谢，都受遗传因素的影响。这些基因中的 DNA 序列变异，即单核苷酸变异（SNVs），可能赋予遗传优势，可以利用这些优势来实现最佳的运动表现。不了解这些特征可能会造成遗传“障碍”，阻碍职业运动员从事体育事业。预测基因组 DNA 分析揭示了与耐力、力量和速度运动更适配相关的单核苷酸变异（SNV）。

（1）背景：在运动员中开展与骨骼肌能量代谢调节相关的候选基因研究。

（2）方法：我们在 SCOPUS、Web of Science、Google Scholar、Clinical keys、PubMed、e-LIBRARY 数据库中，使用关键词和关键词组合，检索了 2010-2020 年期间的文章；

（4）结论：鉴定与骨骼肌能量代谢调节相关的遗传标记，可以帮助运动医师和教练为耐力、力量和速度运动（如慢跑、中长跑等）制定个性化的儿童、青少年和年轻成人选材策略。然而，运动表现的多因素方面，包括遗传、表观遗传、环境（训练等）的影响，对于运动员的选材策略很重要。这种方法可以提高运动表现，降低运动对骨骼肌肉系统造成损伤的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae89/8625318/1c00c0504371/genes-12-01682-g008.jpg
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