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眼部孢子丝菌病

Ocular Sporotrichosis.

作者信息

Ramírez-Soto Max Carlos, Tirado-Sánchez Andrés, Bonifaz Alexandro

机构信息

School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.

Facultad de Ciencias de la Salud, Universidad Tecnológica del Perú, Lima 15046, Peru.

出版信息

J Fungi (Basel). 2021 Nov 10;7(11):951. doi: 10.3390/jof7110951.

Abstract

Sporotrichosis is a subacute or chronic mycosis predominant in tropical and subtropical regions. It is an infection of subcutaneous tissue caused by fungus species, but occasionally resulting in an extracutaneous condition, including osteoarticular, pulmonary, nervous central system, and ocular disease. Cases of ocular sporotrichosis are rare, but reports have been increasing in recent decades. Ocular infections usually occur in hyperendemic areas of sporotrichosis. For its classification, anatomic criteria are used. The clinical presentation is the infection in the ocular adnexal and intraocular infection. Ocular adnexa infections include palpebral, conjunctivitis, and infections of the lacrimal sac. Intraocular infection includes exogenous or endogenous endophthalmitis. Most infections in the ocular adnexal have been reported in Brazil, China and Peru, and intraocular infections are limited to the USA and Brazil. Diagnosis is performed from isolation in the mycological examination from ocular or skin samples. Both sporotrichosis in the ocular adnexa and intraocular infection can mimic several infectious and non-infectious medical conditions. Ocular adnexa infections are treated with potassium iodide and itraconazole. The intraocular infection is treated with amphotericin B. This review describes the clinical findings and epidemiological, diagnosis, and treatment of ocular sporotrichosis.

摘要

孢子丝菌病是一种在热带和亚热带地区常见的亚急性或慢性真菌病。它是由真菌引起的皮下组织感染,但偶尔也会导致皮肤外疾病,包括骨关节、肺部、中枢神经系统和眼部疾病。眼部孢子丝菌病病例罕见,但近几十年来报告不断增加。眼部感染通常发生在孢子丝菌病的高流行地区。对于其分类,采用解剖学标准。临床表现为眼附属器感染和眼内感染。眼附属器感染包括睑部、结膜炎和泪囊感染。眼内感染包括外源性或内源性眼内炎。大多数眼附属器感染报告来自巴西、中国和秘鲁,眼内感染仅限于美国和巴西。诊断通过从眼部或皮肤样本的真菌学检查中分离得出。眼附属器孢子丝菌病和眼内感染都可能模仿几种感染性和非感染性疾病。眼附属器感染用碘化钾和伊曲康唑治疗。眼内感染用两性霉素B治疗。本综述描述了眼部孢子丝菌病的临床发现、流行病学、诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15a9/8621225/72bea84a49cf/jof-07-00951-g001.jpg

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