迈向大血管血管炎研究中可靠的摄取指标。

Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies.

作者信息

van Praagh Gijs D, Nienhuis Pieter H, de Jong Daniel M, Reijrink Melanie, van der Geest Kornelis S M, Brouwer Elisabeth, Glaudemans Andor W J M, Sinha Bhanu, Willemsen Antoon T M, Slart Riemer H J A

机构信息

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

出版信息

Diagnostics (Basel). 2021 Oct 26;11(11):1986. doi: 10.3390/diagnostics11111986.

The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests, while linear correlation analyses were used for age, fat mass, FBGL, and eGFR. Significantly higher SUVs were found in women compared with men, whereas SULs were similar between sexes. In addition, higher fat mass was associated with increased SUVs (r = 0.56 to 0.65; all < 0.001) in the blood pool, but no correlations were found between SULs and fat mass (r = -0.25 to -0.15; all > 0.05). Lower eGFR was associated with a higher FDG blood pool activity for all uptake values. In FDG-PET/CT studies with LVV patients, we recommend using SUL over SUV, while caution is advised in interpreting SUV and SUL measures when patients have impaired kidney function.

本研究旨在调查性别、年龄、脂肪量、空腹血糖水平（FBGL）和估计肾小球滤过率（eGFR）对大血管血管炎（LVV）患者血池活性的影响。在41例LVV患者的氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）中，通过校正体重（SUVs）和去脂体重（SULs）的平均、最大和峰值标准化摄取值，测量上腔静脉的血池活性。用t检验评估性别对血池活性的影响，而对年龄、脂肪量、FBGL和eGFR进行线性相关分析。发现女性的SUVs显著高于男性，而SULs在性别之间相似。此外，较高的脂肪量与血池中SUVs增加相关（r = 0.56至0.65；均P < 0.001），但未发现SULs与脂肪量之间存在相关性（r = -0.25至-0.15；均P > 0.05）。较低的eGFR与所有摄取值时较高的FDG血池活性相关。在LVV患者的FDG-PET/CT研究中，我们建议使用SUL而非SUV，而当患者肾功能受损时，在解释SUV和SUL测量值时应谨慎。