A Machine Learning Model Based on Radiomic Features as a Tool to Identify Active Giant Cell Arteritis on [F]FDG-PET Images During Follow-Up.

: To investigate the feasibility of a machine learning (ML) model based on radiomic features to identify active giant cell arteritis (GCA) in the aorta and differentiate it from atherosclerosis in follow-up [F]FDG-PET/CT images for therapy monitoring. : To train the ML model, 64 [F]FDG-PET scans of 34 patients with proven GCA and 34 control subjects with type 2 diabetes mellitus were retrospectively included. The aorta was delineated into the ascending, arch, descending, and abdominal aorta. From each segment, 95 features were extracted. All segments were randomly split into a training/validation ( = 192; 80%) and test set ( = 46; 20%). In total, 441 ML models were trained, using combinations of seven feature selection methods, seven classifiers, and nine different numbers of features. The performance was assessed by area under the curve (AUC). The best performing ML model was compared to the clinical report of nuclear medicine physicians in 19 follow-up scans (7 active GCA, 12 inactive GCA). For explainability, an occlusion map was created to illustrate the important regions of the aorta for the decision of the ML model. : The ten-feature model with ANOVA as the feature selector and random forest classifier demonstrated the highest performance (AUC = 0.92 ± 0.01). Compared with the clinical report, this model showed a higher PPV (0.83 vs. 0.80), NPV (0.85 vs. 0.79), and accuracy (0.84 vs. 0.79) in the detection of active GCA in follow-up scans. : The current radiomics ML model was able to identify active GCA and differentiate GCA from atherosclerosis in follow-up [F]FDG-PET/CT scans. This demonstrates the potential of the ML model as a monitoring tool in challenging [F]FDG-PET scans of GCA patients.