Chen Da-Yang, Lee Inn-Chi, Wang Xing-An, Wong Swee-Hee
Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Division of Pediatric Neurology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Diagnostics (Basel). 2021 Nov 6;11(11):2056. doi: 10.3390/diagnostics11112056.
Identifying biomarkers for hearing impairments (HIs) in patients with neonatal hypoxic-ischemic encephalopathy (HIE), to initialize early hearing habilitation, is crucial. Seventy-eight neonates with HIE were divided into the following two groups: those with HIs and those without HIs. We compared those patients with 11,837 newborns without HIE, and analyzed the risk factors of HIs among neonatal HIE. Of the 78 patients, 11 were confirmed to have an HI, which is a substantially higher percentage than in the 11,837 newborns without HIE (14.1% vs. 0.87%; < 0.001). More patients with moderate-to-severe HIE had confirmed HIs ( = 0.020; odds ratio, 8.61) than those with mild HIE. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE. The patients who exhibited HIs had significantly higher lactate (104.8 ± 51.0 vs. 71.4 ± 48.4; U = 181, = 0.032) and serum glucose (159.5 ± 86.1 vs. 112.1 ± 62.3; U = 166, = 0.036) levels than those without HIs. A higher prevalence of HIs was noted in the patients with stage III HIE than those with stage II HIE (43.8% vs. 10%; = 0.008). The degree of HI correlated with brain anomalies and neurodevelopmental outcomes at 1 year of age. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE.
识别新生儿缺氧缺血性脑病（HIE）患者听力障碍（HI）的生物标志物，以启动早期听力康复至关重要。78例HIE新生儿被分为以下两组：有HI者和无HI者。我们将这些患者与11837例无HIE的新生儿进行比较，并分析新生儿HIE中HI的危险因素。78例患者中，11例被确诊有HI，这一比例显著高于11837例无HIE的新生儿（14.1%对0.87%；P<0.001）。中度至重度HIE患者确诊有HI的比例（P = 0.020；比值比，8.61）高于轻度HIE患者。临床分期、血乳酸和血糖水平可能是HIE患者HI的预测因素。有HI的患者乳酸水平（104.8±51.0对71.4±48.4；U = 181，P = 0.032）和血清葡萄糖水平（159.5±86.1对112.1±62.3；U = 166，P = 0.036）显著高于无HI的患者。III期HIE患者中HI的患病率高于II期HIE患者（43.8%对10%；P = 0.008）。HI的程度与1岁时的脑异常和神经发育结局相关。临床分期、血乳酸和血糖水平可能是HIE患者HI的预测因素。
