Livzan Maria A, Gaus Olga V, Mozgovoi Sergei I, Bordin Dmitry S
Omsk Sate Medical University, 644099 Omsk, Russia.
A.S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia.
Diagnostics (Basel). 2021 Nov 15;11(11):2113. doi: 10.3390/diagnostics11112113.
This article summarizes and systematizes the available data from the literature on chronic autoimmune gastritis (CAG) in order to increase the awareness of specialists about the modern possibilities for diagnosing the disease, including its early stages. The clinical manifestation of the disease includes possible variants such as gastrointestinal, hematological (first of all, the formation of iron deficiency and B12-deficiency anemia), and neurological variants. Patients with chronic autoimmune gastritis are characterized by comorbidity with other autoimmune diseases. In this paper, data on the most informative serological markers for the diagnosis of CAG, as well as laboratory tests to detect micronutrient deficiencies, information on the characteristic changes in the gastric mucosa, and the prognosis of the disease, are presented. The diagnosis of CAG should be based on a multidisciplinary approach that combines a thorough analysis of a patient's complaints with a mandatory assessment of nutritional status, as well as the results of serological, endoscopic, and histological research methods.
本文总结并系统整理了文献中有关慢性自身免疫性胃炎（CAG）的现有数据，以提高专科医生对该疾病现代诊断方法的认识，包括疾病早期阶段的诊断方法。该疾病的临床表现包括多种可能的类型，如胃肠道型、血液学型（首先是缺铁性贫血和维生素B12缺乏性贫血的形成）以及神经学型。慢性自身免疫性胃炎患者的特点是常合并其他自身免疫性疾病。本文介绍了用于诊断CAG的最具信息价值的血清学标志物数据、检测微量营养素缺乏的实验室检查、胃黏膜特征性变化的信息以及该疾病的预后情况。CAG的诊断应基于多学科方法，该方法将对患者主诉的全面分析与营养状况的强制性评估以及血清学、内镜和组织学研究方法的结果相结合。
