Singh Shubhangi, Chakole Swarupa, Agrawal Suyash, Shetty Nidhi, Prasad Roshan, Lohakare Tejaswee, Wanjari Mayur, Yelne Seema
Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 Aug 13;15(8):e43418. doi: 10.7759/cureus.43418. eCollection 2023 Aug.
Autoimmune gastritis is characterized by inflammation of the gastric mucosa due to autoimmune dysregulation. Upper gastrointestinal symptoms associated with autoimmune gastritis can significantly impact an individual's quality of life and require effective management strategies. This review article provides a comprehensive overview of the current understanding of upper gastrointestinal symptom management in autoimmune gastritis, aiming to consolidate existing knowledge, identify gaps, and offer insights for future research and clinical practice. The review begins by discussing the background and significance of autoimmune gastritis, highlighting its prevalence and the impact of upper gastrointestinal symptoms on affected individuals. The pathophysiology and clinical presentation of autoimmune gastritis-related upper gastrointestinal symptoms are explored, emphasizing the need for accurate diagnosis and targeted management approaches. Diagnostic approaches, including diagnostic criteria, endoscopy, histology, and biomarkers, are critically examined, along with the challenges and limitations associated with diagnosing autoimmune gastritis. The review then delves into the pharmacological approaches for symptom relief, such as proton pump inhibitors (PPIs) and H2 receptor antagonists. It explores the role of dietary modifications and lifestyle changes in symptom control. The article further discusses recent advancements in pharmacological interventions, novel therapeutic approaches, and the potential benefits of complementary and alternative medicine in symptom management. The concept of patient-centered approaches and personalized management strategies is emphasized, highlighting the importance of considering individual patient characteristics, treatment goals, and preferences. Recommendations for future research and clinical management are provided, including exploring emerging therapeutic targets, precision medicine approaches, and collaboration among researchers, clinicians, and patient advocacy groups. The review concludes by emphasizing the significance of implementing the findings and recommendations in clinical practice to enhance patient care and improve the quality of life for individuals with autoimmune gastritis.
自身免疫性胃炎的特征是由于自身免疫失调导致胃黏膜炎症。与自身免疫性胃炎相关的上消化道症状会对个体的生活质量产生重大影响，需要有效的管理策略。这篇综述文章全面概述了目前对自身免疫性胃炎上消化道症状管理的理解，旨在巩固现有知识、找出差距，并为未来的研究和临床实践提供见解。综述首先讨论了自身免疫性胃炎的背景和意义，强调了其患病率以及上消化道症状对受影响个体的影响。探讨了自身免疫性胃炎相关上消化道症状的病理生理学和临床表现，强调了准确诊断和针对性管理方法的必要性。对诊断方法，包括诊断标准、内镜检查、组织学和生物标志物进行了严格审查，以及与诊断自身免疫性胃炎相关的挑战和局限性。然后，综述深入探讨了缓解症状的药物方法，如质子泵抑制剂（PPIs）和H2受体拮抗剂。探讨了饮食调整和生活方式改变在症状控制中的作用。文章进一步讨论了药物干预的最新进展、新型治疗方法以及补充和替代医学在症状管理中的潜在益处。强调了以患者为中心的方法和个性化管理策略的概念，突出了考虑个体患者特征、治疗目标和偏好的重要性。提供了未来研究和临床管理的建议，包括探索新出现的治疗靶点、精准医学方法，以及研究人员、临床医生和患者倡导团体之间的合作。综述最后强调了在临床实践中实施研究结果和建议以加强患者护理并改善自身免疫性胃炎患者生活质量的重要性。
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