Zinellu Elisabetta, Zinellu Angelo, Pau Maria Carmina, Piras Barbara, Fois Alessandro G, Mellino Sabrina, Carru Ciriaco, Mangoni Arduino A, Pirina Pietro
Clinical and Interventional Pulmonology, University Hospital Sassari (AOU), 07100 Sassari, Italy.
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Antioxidants (Basel). 2021 Oct 30;10(11):1745. doi: 10.3390/antiox10111745.
Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = -1.91, 95% CI -2.55 to -1.28, < 0.001; moderate certainty of evidence). By contrast, in 10 studies assessing serum/plasma (GPx isoform 3), the pooled results showed that GPx concentrations were not significantly different between the two groups (very low certainty of evidence). The concentration of GPx-1, but not GPx-3, is significantly lower in COPD patients, suggesting an impairment of antioxidant defense mechanisms in this group.
慢性阻塞性肺疾病（COPD）是一种进行性疾病，其特征为持续的炎症状态和氧化应激。COPD中氧化应激的存在是促氧化剂和抗氧化剂机制失衡的结果。本综述的目的是研究抗氧化防御机制的关键组成部分谷胱甘肽过氧化物酶（GPx）与COPD之间可能存在的关联。从数据库建立至2021年6月，在电子数据库PubMed、科学网、Scopus和谷歌学术中对相关研究进行了系统检索。采用标准化均值差（SMD）来表示COPD患者与非COPD受试者之间GPx浓度的差异。共纳入24项研究。在15项评估全血/红细胞（GPx同工酶1）的研究中，汇总结果显示，COPD患者的GPx浓度显著降低（SMD = -1.91，95%CI -2.55至-1.28，<0.001；证据确定性为中等）。相比之下，在10项评估血清/血浆（GPx同工酶3）的研究中，汇总结果显示两组之间的GPx浓度无显著差异（证据确定性非常低）。COPD患者中GPx-1的浓度显著降低，而GPx-3则不然，这表明该组患者的抗氧化防御机制受损。
