Pothen Lucie, Balligand Jean-Luc
Institute of Experimental and Clinical Research (IREC), Pharmacology and Therapeutics (FATH), Cliniques Universitaires St-Luc and Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.
Antioxidants (Basel). 2021 Nov 22;10(11):1849. doi: 10.3390/antiox10111849.
In medicine, a legacy effect is defined as the sustained beneficial effect of a given treatment on disease outcomes, even after cessation of the intervention. Initially described in optimized control of diabetes, it was also observed in clinical trials exploring intensification strategies for other cardiovascular risk factors, such as hypertension or hypercholesterolemia. Mechanisms of legacy were particularly deciphered in diabetes, leading to the concept of metabolic memory. In a more discreet manner, other memory phenomena were also described in preclinical studies that demonstrated long-lasting deleterious effects of lipids or angiotensin II on vascular wall components. Interestingly, epigenetic changes and reactive oxygen species (ROS) appear to be common features of "memory" of the vascular wall.
在医学领域，遗留效应被定义为即使在干预停止后，特定治疗对疾病结局仍具有持续的有益影响。最初在糖尿病的优化控制中被描述，在探索其他心血管危险因素（如高血压或高胆固醇血症）强化策略的临床试验中也观察到了这种效应。遗留效应的机制在糖尿病中得到了特别的阐释，从而产生了代谢记忆的概念。以一种更为隐秘的方式，临床前研究中也描述了其他记忆现象，这些研究表明脂质或血管紧张素II对血管壁成分具有长期的有害影响。有趣的是，表观遗传变化和活性氧（ROS）似乎是血管壁“记忆”的共同特征。
