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精氨酸酶 2 和多胺在人胰腺β细胞中的作用：在 2 型糖尿病发病机制中的可能作用。

Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes.

机构信息

Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.

出版信息

Int J Mol Sci. 2021 Nov 9;22(22):12099. doi: 10.3390/ijms222212099.

DOI:10.3390/ijms222212099
PMID:34829980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8625980/
Abstract

Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes.

摘要

精氨酸酶 2（ARG2）是一种参与多种组织特异性过程的锰金属酶，从生理学到病理生理学。它在肝外组织中表达不同，位于线粒体中。在人类胰岛β细胞中，ARG2 在 2 型糖尿病中下调。该酶调节多胺的合成，多胺参与胰腺发育和β细胞功能的调节。在这里，我们讨论 ARG2 和多胺的几个特征，这些特征可能与 2 型糖尿病的病理生理学有关。

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