Sánchez-Díaz Manuel, Salvador-Rodríguez Luis, Montero-Vílchez Trinidad, Martínez-López Antonio, Arias-Santiago Salvador, Molina-Leyva Alejandro
Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain.
Dermatology Department, School of Medicine, University of Granada, 18016 Granada, Spain.
J Clin Med. 2021 Nov 9;10(22):5222. doi: 10.3390/jcm10225222.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for biologic therapy and to explore potentially associated factors. A cross-sectional study was performed. Body mass index (BMI), carotid intima-media thickness (IMT), and blood tests, including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were performed. Fifty patients were included in the study; the male/female ratio was 3:2. The mean age was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 μm. A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion, patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be useful clinical and biochemical markers to identify patients at higher risk.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，与代谢和心血管合并症的风险增加有关。本研究的目的是通过内膜中层厚度（IMT）、代谢综合征和其他潜在生物标志物，评估重度化脓性汗腺炎患者（这些患者是生物治疗的候选对象）的心血管风险，并探索潜在的相关因素。进行了一项横断面研究。测量了体重指数（BMI）、颈动脉内膜中层厚度（IMT）以及血液检查，包括血糖和血脂谱、胰岛素、维生素D和炎症标志物。50名患者纳入研究；男女比例为3:2。平均年龄为38岁，平均病程为21.8年。平均颈动脉IMT为651.39μm。观察到IMT与病程、吸烟量和糖化血红蛋白（HbA1c）水平呈正相关。HbA1c与发病年龄、高血压、代谢综合征和血糖水平相关。维生素D水平与受累区域数量呈负相关。总之，重度HS患者存在较高的心血管风险，但在患者中分布不均：吸烟、血糖控制不佳和病程可能是识别高危患者有用的临床和生化标志物。
