Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, AOU Policlinico "G. Martino" (Pad H, 4th Floor), Via Consolare Valeria, 1, 98125, Messina, Italy.
Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Messina, Italy.
J Endocrinol Invest. 2017 Dec;40(12):1337-1343. doi: 10.1007/s40618-017-0707-x. Epub 2017 Jun 14.
Vitamin D has been associated with metabolic disorders and increasing risk of cardiovascular diseases, with conflicting results. Aim of our study was to evaluate the relationship, if any, between cardio-metabolic risk factors and serum 25(OH)D concentrations in healthy women in premenopausal age.
We enrolled 200 healthy women, aged 19-50 years (mean age ± SD, 38 ± 11 years). In each subject, we measured serum 25(OH)D in relation to metabolic biomarkers and cardiovascular parameters.
A status of vitamin D deficiency was found in 48% of the study population, while 38% showed levels higher than 30 ng/ml. Fasting glucose and insulin levels were significantly higher in subjects with vitamin D deficiency/insufficiency (P = 0.034 and P = 0.049, respectively) as well as HOMA-IR (P = 0.05). HDL cholesterol was significantly lower (P = 0.024) and intima-media thickness (IMT) higher (P = 0.014) in the vitamin D deficient/insufficient subjects. Moreover, serum 25(OH)D levels inversely correlated with insulin levels (P = 0.0001) and intima-media thickness (P = 0.015), and directly with serum HDL cholesterol (P = 0.010). At univariate regression analysis, the parameters that were significantly associated with vitamin D levels were insulin (P = 0.050), HDL cholesterol (P = 0.016), and intima-media thickness (P = 0.015). At multivariate analysis adjusted for age and BMI, vitamin D was still significantly associated with HDL cholesterol and intima-media thickness.
A positive association between vitamin D and HDL cholesterol was found in healthy women without any evidence of metabolic disorders, with a significant inverse correlation between vitamin D and IMT. These results suggest a possible protective role of 25(OH)D in cardiovascular disorders.
维生素 D 与代谢紊乱和心血管疾病风险增加有关，但结果存在矛盾。本研究旨在评估绝经前健康女性的心血管代谢危险因素与血清 25（OH）D 浓度之间的关系。
我们招募了 200 名年龄在 19-50 岁（平均年龄±标准差，38±11 岁）的健康女性。在每个受试者中，我们测量了与代谢生物标志物和心血管参数相关的血清 25（OH）D。
研究人群中 48%存在维生素 D 缺乏，38%存在 25（OH）D 水平高于 30ng/ml。维生素 D 缺乏/不足的患者空腹血糖和胰岛素水平显著升高（P=0.034 和 P=0.049），HOMA-IR 也升高（P=0.05）。HDL 胆固醇水平显著降低（P=0.024），内膜-中层厚度（IMT）升高（P=0.014）。此外，血清 25（OH）D 水平与胰岛素水平呈负相关（P=0.0001）和 IMT 呈负相关（P=0.015），与血清 HDL 胆固醇呈正相关（P=0.010）。在单变量回归分析中，与维生素 D 水平显著相关的参数为胰岛素（P=0.050）、HDL 胆固醇（P=0.016）和 IMT（P=0.015）。在调整年龄和 BMI 后的多变量分析中，维生素 D 与 HDL 胆固醇和 IMT 仍显著相关。
在没有任何代谢紊乱证据的健康女性中，维生素 D 与 HDL 胆固醇之间存在正相关，与 IMT 之间存在显著的负相关。这些结果表明 25（OH）D 可能在心血管疾病中发挥保护作用。
