Tsou Yung-An, Chen Sheng-Hwa, Wu Wen-Chieh, Tsai Ming-Hsui, Bassa David, Shih Liang-Chun, Chang Wen-Dien
Department of Otolaryngology-Head and Neck Surgery, China Medical University Hospital, Taichung 40402, Taiwan.
Department of Audiology and Speech-Language Pathology, Asia University, Taichung 41354, Taiwan.
J Clin Med. 2021 Nov 12;10(22):5262. doi: 10.3390/jcm10225262.
Laryngopharyngeal reflux disease (LPRD) might be associated with reflux symptoms, and its severity is correlated with the Reflux Symptoms Index. Diagnosis is often challenging because of a lack of accurate diagnostic tools. Although an association between LPRD and gastroesophageal reflux disease (GERD) exists, the extent to which esophageal pressure changes in patients with LPRD with GERD has been unknown. Therefore, this study surveys the clinical assessments and extent of esophageal pressure changes in LRPD patients with various GERD severities, and compares esophageal sphincter pressures between ages, genders, and body mass index (BMI). This observational study assessed patients with LPRD and GERD. High-resolution esophageal manometry was used to gather data pertaining to the area pressure on the upper esophageal sphincter (UES) and lower esophageal sphincter (LES), and the correlation between such pressure and symptom severity was determined. We compared the esophageal pressure of different UES and LES levels in the following categories: gender, age, BMI, and GERD severity. We analyzed correlations between esophageal pressure and clinical assessments among 90 patients with throat globus with laryngitis with LPRD. LPRD was measured using laryngoscopy, and GERD was measured using esophagoscopy and 24 h PH monitoring. There were no significant differences in the clinical assessments among the four grades of GERD. The LPRD patients with serious GERD had a lower UES and LES pressure. The lowest pressure and longer duration of LES and UES were also observed among patients with LPRD of grade D GERD. No significant differences in UES and LES pressures among ages, genders, or BMIs were noted.
喉咽反流病（LPRD）可能与反流症状相关，其严重程度与反流症状指数相关。由于缺乏准确的诊断工具，诊断往往具有挑战性。虽然LPRD与胃食管反流病（GERD）之间存在关联，但LPRD合并GERD患者食管压力变化的程度尚不清楚。因此，本研究调查了不同GERD严重程度的LRPD患者的临床评估和食管压力变化程度，并比较了不同年龄、性别和体重指数（BMI）之间的食管括约肌压力。这项观察性研究评估了LPRD和GERD患者。使用高分辨率食管测压法收集有关食管上括约肌（UES）和食管下括约肌（LES）区域压力的数据，并确定这种压力与症状严重程度之间的相关性。我们比较了以下类别中不同UES和LES水平的食管压力：性别、年龄、BMI和GERD严重程度。我们分析了90例患有LPRD伴喉炎的咽异感症患者的食管压力与临床评估之间的相关性。使用喉镜检查测量LPRD，使用食管镜检查和24小时pH监测测量GERD。GERD的四个等级之间的临床评估没有显著差异。严重GERD的LPRD患者UES和LES压力较低。在D级GERD的LPRD患者中也观察到LES和UES的最低压力和最长持续时间。在年龄、性别或BMI之间的UES和LES压力方面未发现显著差异。
