and in a Kenyan Maasai Adolescent Population and Inhibition of Leukotoxic Activity by Herbal Plants Used as Part of Oral Hygiene Procedures.

BACKGROUND

A virulent genotype (JP2) of the periodonto-pathogen, (), is widespread in North and West Africa, while its presence in East Africa has not been thoroughly investigated. This JP2 genotype is associated with periodontitis in adolescents and has a high leukotoxicity. The aim of the study was to examine the prevalence of and its JP2 genotype, the prevalence of the oral, commensal in a Maasai adolescent population, and the effect of herbal plants for inhibition of leukotoxicity.

METHODS

A total of 284 adolescents from Maasai Mara, Kenya, underwent an oral examination and microbial sampling. The presence of and was analyzed by quantitative PCR and cultivation (the 58 samples collected at the last day of field study). The collected strains were characterized and leukotoxin promoter typed. Additionally, herbal plants commonly used for oral hygiene were assessed for the inhibition of leukotoxicity.

RESULTS AND CONCLUSIONS

The prevalence of in stimulated whole saliva was high (71.8%), with the JP2 genotype detected in one individual, and in 99% of the sampled individuals. The commonly used herbal plant, , inactivated leukotoxicity. The virulence might be reduced through use of and the high levels of .