Waśkiel-Burnat Anna, Niemczyk Anna, Blicharz Leszek, Chmielińska Paulina, Zaremba Michał, Gąsecka Aleksandra, Filipiak Krzysztof J, Olszewska Małgorzata, Rudnicka Lidia
Department of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland.
1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.
J Clin Med. 2021 Nov 19;10(22):5418. doi: 10.3390/jcm10225418.
Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281, = 0.03), while GDF15 correlated with age at the disease onset (r = 0.509, < 0.0001). The results of the present study suggest that the severity of alopecia areata may be associated with an increased risk of atherosclerosis.
斑秃是一种自身免疫性炎症性非瘢痕性脱发，可累及任何有毛发的区域。最近，有研究描述斑秃患者患心血管疾病的风险增加。本研究的目的是评估与动脉粥样硬化相关的促炎蛋白（趋化因子C-C基序配体4；CCL4、趋化因子C-C基序配体7、CCL7；和sortilin，SORT1）以及心血管风险（髓过氧化物酶，MPO；白细胞介素1受体样1，IL1RL1；和生长分化因子15，GDF15）在无症状或无既往心血管疾病的斑秃患者中的血清浓度，并与健康对照进行比较。60名其他方面健康的斑秃患者和20名年龄、性别和体重指数（BMI）匹配的对照受试者被纳入研究。在斑秃患者和健康对照之间，未检测到MPO、IL1RL1、CCL4、CCL7、SORT1和GDF15血清水平的显著差异。发现CCL7的血清浓度与斑秃的严重程度呈正相关（r = 0.281，P = 0.03），而GDF15与疾病发病年龄相关（r = 0.509，P < 0.0001）。本研究结果表明，斑秃的严重程度可能与动脉粥样硬化风险增加有关。
