Nowowiejska Julia, Baran Anna, Krahel Julita A, Kamiński Tomasz W, Maciaszek Magdalena, Flisiak Iwona
Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland.
Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Metabolites. 2022 Apr 9;12(4):340. doi: 10.3390/metabo12040340.
Psoriasis is a common inflammatory skin disease, which is tightly associated with metabolic disorders. Cholesteryl ester transfer protein (CETP) and sortilin (SORT) are molecules engaged in lipid metabolism of proatherogenic properties. They have been hardly ever studied in psoriasis before. Serum CETP and SORT concentrations were measured in 33 patients with plaque-type psoriasis before and after 12 weeks of treatment with methotrexate or acitretin. There was no significant difference in CEPT and SORT serum concentrations between patients and controls. Positive correlations between CETP after the treatment with acitretin and activity of transaminases (R = 0.65, R = 0.56, respectively) were noted. CETP was positively related with triglycerides (R = 0.49), glucose (R = 0.54) and CRP (R = 0.64) before the treatment with methotrexate, which all disappeared afterwards. Systemic therapy with methotrexate caused normalization of SORT concentration. There was significant correlation between SORT and WBC (p < 0.01) and CRP (p < 0.05). CETP and SORT cannot be used as individual biomarkers. Nevertheless, they show some interesting relations with other parameters. Increased concentration of CETP perhaps could investigated as a marker of liver side effects of acitretin treatment in psoriatics. SORT could be considered as a new indicator of metabolically induced inflammation in psoriasis. Methotrexate may be preferred in patients with high SORT concentrations. Further studies are needed to establish their exact role in psoriatic patients.
银屑病是一种常见的炎症性皮肤病，与代谢紊乱密切相关。胆固醇酯转运蛋白（CETP）和sortilin（SORT）是具有促动脉粥样硬化特性的参与脂质代谢的分子。此前它们在银屑病中几乎从未被研究过。对33例斑块型银屑病患者在接受甲氨蝶呤或阿维A治疗12周前后测定血清CETP和SORT浓度。患者与对照组之间的CEPT和SORT血清浓度无显著差异。注意到阿维A治疗后CETP与转氨酶活性之间呈正相关（分别为R = 0.65，R = 0.56）。在甲氨蝶呤治疗前，CETP与甘油三酯（R = 0.49）、葡萄糖（R = 0.54）和CRP（R = 0.64）呈正相关，治疗后这些相关性均消失。甲氨蝶呤全身治疗使SORT浓度恢复正常。SORT与白细胞（p < 0.01）和CRP（p < 0.05）之间存在显著相关性。CETP和SORT不能用作单独的生物标志物。然而，它们与其他参数显示出一些有趣的关系。CETP浓度升高或许可作为银屑病患者阿维A治疗肝脏副作用的标志物进行研究。SORT可被视为银屑病中代谢诱导炎症的新指标。对于SORT浓度高的患者，甲氨蝶呤可能更适用。需要进一步研究以确定它们在银屑病患者中的确切作用。
