Souto Eliana B, de Souza Ana L R, Dos Santos Fernanda K, Sanchez-Lopez Elena, Cano Amanda, Zielińska Aleksandra, Staszewski Rafał, Karczewski Jacek, Gremião Maria P D, Chorilli Marlus
CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Faculty of Pharmaceutical Sciences, São Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Jaú, Araraquara 14800-903, SP, Brazil.
Cancers (Basel). 2021 Nov 10;13(22):5619. doi: 10.3390/cancers13225619.
Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.
增生性皮肤病（HSD）是一类疾病，包括癌症、癌前病变和病因不明的疾病，这些疾病在损伤的程度和分布方面表现出不同的皮肤表现。用于治疗这些疾病的抗增殖剂种类繁多，一般包括5-氨基酮戊酸、5-氟尿嘧啶、咪喹莫特、甲氨蝶呤、紫杉醇、鬼臼毒素、雄黄和皮质类固醇。这些药物通常水溶性较低，因此会降低皮肤渗透性。因此，有人提出将它们载入脂质纳米载体，主要目的是提高局部治疗的有效性并减少副作用。本手稿旨在描述使用脂质纳米颗粒和脂质体的优势，这些脂质纳米颗粒和脂质体可用于装载多种化学性质不同的药物来治疗增生性皮肤病。
