Beckwith Kyle A, Byrd John C, Muthusamy Natarajan
Division of Hematology, Department of Internal Medicine, The Ohio State University Columbus, OH, USA.
Division of Hematology, Department of Internal Medicine, The Ohio State University Columbus, OH, USA ; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University Columbus, OH, USA.
Front Physiol. 2015 Mar 23;6:91. doi: 10.3389/fphys.2015.00091. eCollection 2015.
Tetraspanins belong to a family of transmembrane proteins which play a major role in the organization of the plasma membrane. While all immune cells express tetraspanins, most of these are present in a variety of other cell types. There are a select few, such as CD37 and CD53, which are restricted to hematopoietic lineages. Tetraspanins associate with numerous partners involved in a diverse set of biological processes, including cell activation, survival, proliferation, adhesion, and migration. The historical view has assigned them a scaffolding role, but recent discoveries suggest some tetraspanins can directly participate in signaling through interactions with cytoplasmic proteins. Given their potential roles in supporting tumor survival and immune evasion, an improved understanding of tetraspanin activity could prove clinically valuable. This review will focus on emerging data in the study of tetraspanins, advances in the clinical development of anti-CD37 therapeutics, and the future prospects of targeting tetraspanins in hematological malignancy.
四跨膜蛋白属于跨膜蛋白家族，在质膜组织中起主要作用。虽然所有免疫细胞都表达四跨膜蛋白，但其中大多数也存在于多种其他细胞类型中。有少数几种，如CD37和CD53，仅限于造血谱系。四跨膜蛋白与参与多种生物过程的众多伙伴相互作用，包括细胞活化、存活、增殖、黏附和迁移。传统观点认为它们起支架作用，但最近的发现表明，一些四跨膜蛋白可通过与细胞质蛋白相互作用直接参与信号传导。鉴于它们在支持肿瘤存活和免疫逃逸方面的潜在作用，更好地了解四跨膜蛋白的活性可能具有临床价值。本综述将重点关注四跨膜蛋白研究中的新数据、抗CD37疗法临床开发的进展以及靶向四跨膜蛋白治疗血液系统恶性肿瘤的未来前景。
