Xunian Zhou, Kalluri Raghu
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Department of Bioengineering, Rice University, Houston, Texas, USA.
Cancer Sci. 2020 Sep;111(9):3100-3110. doi: 10.1111/cas.14563. Epub 2020 Jul 28.
Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion of soluble factors, in particular exosomes. MSC-derived exosomes are involved in intercellular communication through transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel intercellular communication mode. This review illustrates the current knowledge on the composition and biological functions as well as the therapeutic potential of MSC-derived exosomes in cancer, with a focus on clinical translation opportunities.
间充质干细胞（MSC）是多能基质细胞，具有分化为多种细胞类型的潜力。基于MSC的治疗已成为治疗各种疾病的一种有前景的策略。越来越多的证据表明，MSC的旁分泌作用部分是通过可溶性因子，特别是外泌体的分泌来发挥的。MSC来源的外泌体通过蛋白质、RNA、DNA和生物活性脂质的传递参与细胞间通讯，这可能构成一种新的细胞间通讯模式。本综述阐述了目前关于MSC来源外泌体的组成、生物学功能及其在癌症中的治疗潜力的知识，重点关注临床转化机会。
