Tollefsen Sofie Eline, Jarmund Anders H, Ytterhus Borgny, Salvesen Øyvind, Mjønes Patricia, Torp Sverre Helge
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
Cancers (Basel). 2021 Nov 15;13(22):5704. doi: 10.3390/cancers13225704.
Meningiomas have high recurrence rates despite frequently benign histopathological appearances. Somatostatin receptors (SSTRs) may be reliable biomarkers that could identify patients with increased risk of recurrence. Even though SSTRs are previously detected in meningiomas, their associations to clinicopathological features remain unclear. The aim of this study was to investigate the diagnostic and prognostic value of SSTRs in a large series of human meningiomas with long follow-up data. Immunohistochemistry was used to measure the expression of SSTR1-SSTR5 in tissue samples from 162 patients diagnosed with intracranial meningiomas of World Health Organization (WHO) grade 1 or 2. Digital scoring and a manual staining index were applied to assess immunoreactivity. All SSTRs, except SSTR4, were upregulated in our series of meningiomas. SSTR1 ( = 0.036), SSTR2 ( = 0.036) and SSTR5 ( = 0.029) were associated with a higher malignancy grade. SSTR2 presented as the most reliable marker. Only SSTR2 was associated with time to recurrence (TTR) in univariate Cox regression analyses. Manual staining index was strongly correlated with digital scoring for all SSTRs ( > 0.65, < 0.001). SSTRs, and especially SSTR2, are useful in the diagnostics of meningiomas, even though their prognostic value appears limited. Digital scoring is valuable to ensure reproducibility.
尽管脑膜瘤的组织病理学表现通常为良性，但其复发率很高。生长抑素受体（SSTRs）可能是可靠的生物标志物，可用于识别复发风险增加的患者。尽管此前已在脑膜瘤中检测到SSTRs，但其与临床病理特征的关联仍不清楚。本研究的目的是在一系列具有长期随访数据的人类脑膜瘤中研究SSTRs的诊断和预后价值。采用免疫组织化学方法检测162例世界卫生组织（WHO）1级或2级颅内脑膜瘤患者组织样本中SSTR1 - SSTR5的表达。应用数字评分和手动染色指数评估免疫反应性。在我们的脑膜瘤系列中，除SSTR4外，所有SSTRs均上调。SSTR1（P = 0.036）、SSTR2（P = 0.036）和SSTR5（P = 0.029）与更高的恶性等级相关。SSTR2是最可靠的标志物。在单变量Cox回归分析中，只有SSTR2与复发时间（TTR）相关。所有SSTRs的手动染色指数与数字评分均高度相关（r > 0.65，P < 0.001）。SSTRs，尤其是SSTR2，在脑膜瘤的诊断中有用，尽管其预后价值似乎有限。数字评分对于确保可重复性很有价值。
