Arduino Paolo G, Magliano Alessandro, Gambino Alessio, Macciotta Alessandra, Carbone Mario, Conrotto Davide, Karimi Dora, Carrozzo Marco, Broccoletti Roberto
Department of Surgical Science, Oral Medicine Section, CIR-Dental School, University of Turin, 10126 Turin, Italy.
Department of Clinical and Biological Sciences, University of Turin, 10126 Turin, Italy.
Cancers (Basel). 2021 Nov 16;13(22):5740. doi: 10.3390/cancers13225740.
Oral lichen planus (OLP) is considered an oral potentially malignant disorder. The aim of our study was to estimate the risk for oral cancer in patients diagnosed with OLP.
A population-based cohort study between January 1988 and December 2020 at one hospital in Northern Italy was performed. The primary endpoint of the study was that of the histopathological diagnosis of oral cancer during the follow-up period.
The study population comprised 3173 patients. During the follow-up period, 32 men and 50 women developed an oral squamous cell carcinoma (2.58%), with a mean time of 103.61 months after the initial diagnosis of OLP, and 21 patients died because of oral cancer. Almost half of the deceased patients had the last follow-up visit before cancer diagnosis in a period of more than 12 months. Older age, having a red form of OLP and fewer sites of involvement, increased the risk of having cancer, while age and no treatment increased the risk of death.
This is the largest group of OLP patients with such a long follow up ever reported. Due to the increased risk of having a malignant transformation, especially in elderly subjects, OLP patients should be regularly followed up, particularly in the Northern Italian population.
口腔扁平苔藓（OLP）被认为是一种口腔潜在恶性疾病。我们研究的目的是评估被诊断为OLP的患者患口腔癌的风险。
于1988年1月至2020年12月在意大利北部的一家医院进行了一项基于人群的队列研究。该研究的主要终点是随访期间口腔癌的组织病理学诊断。
研究人群包括3173名患者。在随访期间，32名男性和50名女性发生了口腔鳞状细胞癌（2.58%），自最初诊断OLP后的平均时间为103.61个月，21名患者因口腔癌死亡。几乎一半的死亡患者在癌症诊断前的最后一次随访时间超过12个月。年龄较大、患有红色型OLP且受累部位较少会增加患癌风险，而年龄较大且未接受治疗会增加死亡风险。
这是有史以来报道的随访时间如此之长的最大一组OLP患者。由于发生恶性转化的风险增加，尤其是在老年患者中，OLP患者应定期接受随访，特别是在意大利北部人群中。
