头颈部肿瘤发生、转移及抗肿瘤治疗耐药中的肿瘤干细胞异质性。
Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours.
机构信息
Melbourne Dental School, The University of Melbourne, Carlton, VIC 3053, Australia.
Centre for Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
出版信息
Cells. 2021 Nov 8;10(11):3068. doi: 10.3390/cells10113068.
Abstract
The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, distinct HNCSC subsets play different roles in the generation and progression of tumours. This article aims to review the evidence for a role of specific CSCs in HNSCC tumorigenesis, invasion, and metastasis, together with resistance to treatment.
摘要
一小部分具有自我更新特性的癌细胞的发现，这些细胞能够产生表型多样化的肿瘤群体，这改变了我们对癌症生物学的理解。针对癌症干细胞（CSCs）已成为各种恶性肿瘤的一种有前途的治疗策略，包括头颈部鳞状细胞癌（HNSCC）。先前已经使用 CSC 特异性标记物鉴定了头颈部癌症干细胞（HNCSC）的多种亚群，最常见的是 CD44、醛脱氢酶 1（ALDH1）和 CD133，或通过侧群测定法。有趣的是，不同的 HNCSC 亚群在肿瘤的发生和进展中发挥不同的作用。本文旨在综述特定 CSCs 在 HNSCC 肿瘤发生、侵袭和转移以及治疗耐药性中的作用证据。
相似文献
1
Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours.
Cells. 2021 Nov 8;10(11):3068. doi: 10.3390/cells10113068.
2
Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition.
Mol Carcinog. 2017 Feb;56(2):694-711. doi: 10.1002/mc.22526. Epub 2016 Aug 4.
3
MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells.
J Pathol. 2011 Mar;223(4):482-95. doi: 10.1002/path.2826. Epub 2011 Jan 5.
4
Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma.
Head Neck. 2015 Mar;37(3):317-26. doi: 10.1002/hed.23600. Epub 2014 Mar 25.
5
Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells.
Neoplasia. 2017 Dec;19(12):1003-1011. doi: 10.1016/j.neo.2017.09.003. Epub 2017 Nov 6.
6
Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells.
Int J Mol Sci. 2017 Aug 24;18(9):1849. doi: 10.3390/ijms18091849.
7
Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2.
J Natl Cancer Inst. 2016 Sep 15;109(1). doi: 10.1093/jnci/djw189. Print 2017 Jan.
8
Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells.
Mol Cancer Ther. 2010 Nov;9(11):2879-92. doi: 10.1158/1535-7163.MCT-10-0504. Epub 2010 Nov 9.
9
Cancer stem cells enrichment with surface markers CD271 and CD44 in human head and neck squamous cell carcinomas.
Carcinogenesis. 2020 Jun 17;41(4):458-466. doi: 10.1093/carcin/bgz182.
10
Up-regulation of Histone Methyltransferase, DOT1L, by Matrix Hyaluronan Promotes MicroRNA-10 Expression Leading to Tumor Cell Invasion and Chemoresistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma.
J Biol Chem. 2016 May 13;291(20):10571-85. doi: 10.1074/jbc.M115.700021. Epub 2016 Mar 21.
引用本文的文献
1
The antitumor effect of tlr4 inhibition in head and neck cancer cell lines.
Sci Rep. 2025 Aug 28;15(1):31681. doi: 10.1038/s41598-025-15927-4.
2
Cancer stem cells: landscape, challenges and emerging therapeutic innovations.
Signal Transduct Target Ther. 2025 Aug 5;10(1):248. doi: 10.1038/s41392-025-02360-2.
3
Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma.
Sci Rep. 2025 Apr 16;15(1):13137. doi: 10.1038/s41598-025-98003-1.
4
Strategies to Overcome Intrinsic and Acquired Resistance to Chemoradiotherapy in Head and Neck Cancer.
Cells. 2024 Dec 27;14(1):18. doi: 10.3390/cells14010018.
5
Correlation between clinicopathological indices and expression of cluster of differentiation 24 and cluster of differentiation 44 biomarkers in oral epithelial dysplasia and oral squamous cell carcinoma patients: A follow-up study.
Dent Res J (Isfahan). 2024 Aug 21;21:50. eCollection 2024.
6
Methods for Overcoming Chemoresistance in Head and Neck Squamous Cell Carcinoma: Keeping the Focus on Cancer Stem Cells, a Systematic Review.
Cancers (Basel). 2024 Aug 29;16(17):3004. doi: 10.3390/cancers16173004.
7
Role of CD44 in Chemotherapy Treatment Outcome: A Scoping Review of Clinical Studies.
Int J Mol Sci. 2024 Mar 8;25(6):3141. doi: 10.3390/ijms25063141.
8
: A Key Player in the Novel Disulfidptosis-Related LncRNA Prognostic Signature for Head and Neck Squamous Cell Carcinoma.
Biomolecules. 2024 Feb 23;14(3):266. doi: 10.3390/biom14030266.
9
The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer.
Int J Mol Sci. 2023 Oct 31;24(21):15812. doi: 10.3390/ijms242115812.
10
Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance.
Genes Dis. 2023 Jan 14;11(1):189-204. doi: 10.1016/j.gendis.2022.11.025. eCollection 2024 Jan.
本文引用的文献
1
Discrimination of Cancer Stem Cell Markers ALDH1A1, BCL11B, BMI-1, and CD44 in Different Tissues of HNSCC Patients.
Curr Oncol. 2021 Jul 19;28(4):2763-2774. doi: 10.3390/curroncol28040241.
2
Cancer Cell CD44 Mediates Macrophage/Monocyte-Driven Regulation of Head and Neck Cancer Stem Cells.
Cancer Res. 2020 Oct 1;80(19):4185-4198. doi: 10.1158/0008-5472.CAN-20-1079. Epub 2020 Aug 14.
3
Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.
Cells. 2020 Jul 16;9(7):1707. doi: 10.3390/cells9071707.
4
The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas.
Cells. 2020 Mar 15;9(3):723. doi: 10.3390/cells9030723.
5
The molecular markers of cancer stem cells in head and neck tumors.
J Cell Physiol. 2020 Jan;235(1):65-73. doi: 10.1002/jcp.28963. Epub 2019 Jun 17.
6
Mesenchymal splice isoform of CD44 (CD44s) promotes EMT/invasion and imparts stem-like properties to ovarian cancer cells.
J Cell Biochem. 2018 Apr;119(4):3373-3383. doi: 10.1002/jcb.26504. Epub 2018 Jan 4.
7
Cancer stem cell markers in patterning differentiation and in prognosis of oral squamous cell carcinoma.
Tumour Biol. 2017 Jun;39(6):1010428317703656. doi: 10.1177/1010428317703656.
8
CD44+ cancer cell-induced metastasis: A feasible neck metastasis model.
Eur J Pharm Sci. 2017 Apr 1;101:243-250. doi: 10.1016/j.ejps.2017.02.020. Epub 2017 Feb 13.
9
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
Oncotarget. 2017 Feb 7;8(6):9557-9571. doi: 10.18632/oncotarget.13771.
10
Identification, expansion and characterization of cancer cells with stem cell properties from head and neck squamous cell carcinomas.
Exp Cell Res. 2016 Oct 15;348(1):75-86. doi: 10.1016/j.yexcr.2016.09.003. Epub 2016 Sep 9.
Zotero 插件