头颈部肿瘤发生、转移及抗肿瘤治疗耐药中的肿瘤干细胞异质性。
Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours.
机构信息
Melbourne Dental School, The University of Melbourne, Carlton, VIC 3053, Australia.
Centre for Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
出版信息
Cells. 2021 Nov 8;10(11):3068. doi: 10.3390/cells10113068.
Abstract
The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, distinct HNCSC subsets play different roles in the generation and progression of tumours. This article aims to review the evidence for a role of specific CSCs in HNSCC tumorigenesis, invasion, and metastasis, together with resistance to treatment.
摘要
一小部分具有自我更新特性的癌细胞的发现，这些细胞能够产生表型多样化的肿瘤群体，这改变了我们对癌症生物学的理解。针对癌症干细胞（CSCs）已成为各种恶性肿瘤的一种有前途的治疗策略，包括头颈部鳞状细胞癌（HNSCC）。先前已经使用 CSC 特异性标记物鉴定了头颈部癌症干细胞（HNCSC）的多种亚群，最常见的是 CD44、醛脱氢酶 1（ALDH1）和 CD133，或通过侧群测定法。有趣的是，不同的 HNCSC 亚群在肿瘤的发生和进展中发挥不同的作用。本文旨在综述特定 CSCs 在 HNSCC 肿瘤发生、侵袭和转移以及治疗耐药性中的作用证据。
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本文引用的文献
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Curr Oncol. 2021 Jul 19;28(4):2763-2774. doi: 10.3390/curroncol28040241.
2
Cancer Cell CD44 Mediates Macrophage/Monocyte-Driven Regulation of Head and Neck Cancer Stem Cells.肿瘤细胞 CD44 介导巨噬细胞/单核细胞对头颈部癌症干细胞的调控作用。
Cancer Res. 2020 Oct 1;80(19):4185-4198. doi: 10.1158/0008-5472.CAN-20-1079. Epub 2020 Aug 14.
3
Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.头颈部癌症干细胞富集球体模型用于抗癌化合物筛选。
Cells. 2020 Jul 16;9(7):1707. doi: 10.3390/cells9071707.
4
The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas.经典 Wnt 信号通路失调在头颈部鳞状细胞癌中的意义。
Cells. 2020 Mar 15;9(3):723. doi: 10.3390/cells9030723.
5
The molecular markers of cancer stem cells in head and neck tumors.头颈部肿瘤中癌症干细胞的分子标志物。
J Cell Physiol. 2020 Jan;235(1):65-73. doi: 10.1002/jcp.28963. Epub 2019 Jun 17.
6
Mesenchymal splice isoform of CD44 (CD44s) promotes EMT/invasion and imparts stem-like properties to ovarian cancer cells.间质剪接异构体 CD44（CD44s）促进 EMT/侵袭，并赋予卵巢癌细胞干细胞样特性。
J Cell Biochem. 2018 Apr;119(4):3373-3383. doi: 10.1002/jcb.26504. Epub 2018 Jan 4.
7
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Tumour Biol. 2017 Jun;39(6):1010428317703656. doi: 10.1177/1010428317703656.
8
CD44+ cancer cell-induced metastasis: A feasible neck metastasis model.CD44+癌细胞诱导的转移：一种可行的颈部转移模型。
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9
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.表皮生长因子通过促进瓦伯格效应诱导人源口腔癌细胞发生上皮-间质转化及癌症干细胞样特性。
Oncotarget. 2017 Feb 7;8(6):9557-9571. doi: 10.18632/oncotarget.13771.
10
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Exp Cell Res. 2016 Oct 15;348(1):75-86. doi: 10.1016/j.yexcr.2016.09.003. Epub 2016 Sep 9.
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