Melbourne Dental School, The University of Melbourne, Carlton, VIC 3053, Australia.
Centre for Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
Cells. 2021 Nov 8;10(11):3068. doi: 10.3390/cells10113068.
The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, distinct HNCSC subsets play different roles in the generation and progression of tumours. This article aims to review the evidence for a role of specific CSCs in HNSCC tumorigenesis, invasion, and metastasis, together with resistance to treatment.
一小部分具有自我更新特性的癌细胞的发现，这些细胞能够产生表型多样化的肿瘤群体，这改变了我们对癌症生物学的理解。针对癌症干细胞（CSCs）已成为各种恶性肿瘤的一种有前途的治疗策略，包括头颈部鳞状细胞癌（HNSCC）。先前已经使用 CSC 特异性标记物鉴定了头颈部癌症干细胞（HNCSC）的多种亚群，最常见的是 CD44、醛脱氢酶 1（ALDH1）和 CD133，或通过侧群测定法。有趣的是，不同的 HNCSC 亚群在肿瘤的发生和进展中发挥不同的作用。本文旨在综述特定 CSCs 在 HNSCC 肿瘤发生、侵袭和转移以及治疗耐药性中的作用证据。
