School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan.
Department of Pharmacy Practice, Tri-Service General Hospital, Taipei 11490, Taiwan.
Int J Environ Res Public Health. 2021 Nov 13;18(22):11945. doi: 10.3390/ijerph182211945.
The use of illegal drugs may be a risk factor of hearing loss. However, very few studies with large sample size have investigated the relationship between illegal drug use and hearing loss. Therefore, to evaluate the association between illegal drug use and hearing loss, this cross-sectional population-based study collected data from the US National Health and Nutrition Examination Survey 2011. The study included 1772 participants aged 20 to 59 years who underwent the Drug Use Questionnaire and Audiometry Examination. Of the 1772 participants in this study, 865 were men (48.8%) and 497 were illegal drug users. The mean (SD) age of the patients was 40.0 (11.4) years. After considering age, sex, and comorbidities, the participants who used illegal drugs were found to have higher risks of high-frequency hearing loss (adjusted odds ratio (OR), 1.69; 95% confidence interval (CI), 1.35-2.10) and overall hearing loss (adjusted OR, 1.69; 95% CI, 1.36-2.12) as compared with the nonusers. In the second analysis, the participants who used ≥ 2 types of illegal drugs were associated with higher risks of high-frequency hearing loss (adjusted OR, 1.57; 95% CI, 1.06-2.32) and overall hearing loss (adjusted OR, 1.60; 95% CI, 1.08-2.37). In the third analysis, cocaine use was associated with increased risks of high-frequency hearing loss (adjusted OR, 1.34; 95% CI, 1.01-1.77) and overall hearing loss (adjusted OR, 1.38; 95% CI, 1.04-1.82). The adjusted OR for overall hearing loss in the methamphetamine users was 1.54 (95% CI, 1.05-2.27) as compared with that in the nonusers. This study shows that illegal drug users might have a higher risk of overall hearing loss than nonusers. In addition, the analysis results demonstrated that the more kinds of illegal drugs used, the higher the risk of hearing loss. Further experimental and longitudinal research studies are required to confirm the causal relationship between illegal drug use and hearing loss.
使用非法药物可能是听力损失的一个风险因素。然而，很少有大样本量的研究调查非法药物使用与听力损失之间的关系。因此，为了评估非法药物使用与听力损失之间的关联，这项基于人群的横断面研究从美国国家健康和营养检查调查 2011 年收集数据。研究纳入了 1772 名年龄在 20 至 59 岁之间的参与者，他们接受了药物使用问卷和听力检查。在这项研究的 1772 名参与者中，865 名是男性（48.8%），497 名是非法药物使用者。患者的平均（SD）年龄为 40.0（11.4）岁。在考虑年龄、性别和合并症后，与非使用者相比，使用非法药物的参与者高频听力损失（校正优势比（OR），1.69；95%置信区间（CI），1.35-2.10）和总体听力损失（校正 OR，1.69；95% CI，1.36-2.12）的风险更高。在第二项分析中，使用≥2 种非法药物的参与者高频听力损失（校正 OR，1.57；95% CI，1.06-2.32）和总体听力损失（校正 OR，1.60；95% CI，1.08-2.37）的风险更高。在第三项分析中，可卡因使用与高频听力损失（校正 OR，1.34；95% CI，1.01-1.77）和总体听力损失（校正 OR，1.38；95% CI，1.04-1.82）的风险增加有关。与非使用者相比，使用冰毒的参与者总体听力损失的校正 OR 为 1.54（95% CI，1.05-2.27）。这项研究表明，非法药物使用者可能比非使用者整体听力损失的风险更高。此外，分析结果表明，使用的非法药物种类越多，听力损失的风险越高。需要进一步的实验和纵向研究来证实非法药物使用与听力损失之间的因果关系。
