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迁延性流离失所对与治疗结果相关的诊断延迟的影响:巴基斯坦国内结核患者的一项横断面研究。

Impact of Protracted Displacement on Delay in the Diagnosis Associated with Treatment Outcomes: A Cross-Sectional Study in Internally Displaced Tuberculosis Patients of Pakistan.

机构信息

Department of Pharmacy Administration and Clinical Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.

Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an 710061, China.

出版信息

Int J Environ Res Public Health. 2021 Nov 15;18(22):11984. doi: 10.3390/ijerph182211984.

DOI:10.3390/ijerph182211984
PMID:34831746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8621790/
Abstract

Human displacement is on the rise globally, and the increase in the burden of tuberculosis (TB) is also attributed to migrations worldwide. A significant number of such displacements occur in regions with considerably higher areas of TB burden. Displacements may delay TB diagnosis and treatment, which will possibly lead to TB transmission among healthy individuals. In this study, we assessed the association of existing determinants after a protracted internal displacement of people with delay in TB diagnosis and treatment outcomes. A cross-sectional study was conducted on internally displaced TB patients (IDPs), registered at selected health facilities in three urban districts of Pakistan from March 2019 to February 2020. The univariate and multivariate logistic regression model was used to assess the delay in diagnosis and treatment outcomes. IDPs with delay in initiation of treatment beyond 30 days were at high possibility of unsuccessful TB treatment outcomes (adjusted odds ratio AOR, 2.60; 95% CI 1.06-6.40). Furthermore, the multivariate regression analysis showed a statistically significant association ( > 0.05) between TB patients who were aged 55 to 65 years (AOR, 2.66; 95% CI 1.00-7.07), female patients (AOR, 2.42; 95% CI 1.21-4.81), visited non-formal health provider (AOR, 8.81; 95% CI 3.99-19.46), self-medication (AOR, 2.72; 95 % CI 1.37-5.37), poor knowledge of TB (AOR, 11.39; 95% CI 3.31-39.1), and perceived stigma (AOR, 8.81; 95% CI 3.99-19.4). Prolonged delay in treatment was associated with unfavorable treatment outcomes among IDPs. Migrants and IDPs are more likely to experience an interruption in care due to overall exclusion from social and health care services. Therefore, it is imperative to understand the barriers to providing public health care services, particularly in preventing and treating TB.

摘要

全球范围内,人类流离失所的现象日益增多,而结核病(TB)负担的增加也与世界各地的移民有关。在结核病负担相当高的地区,发生了大量这样的流离失所。流离失所可能会延迟结核病的诊断和治疗,这可能会导致健康人群之间的结核病传播。在这项研究中,我们评估了在人们经历长期内部流离失所后,现有决定因素与结核病诊断和治疗结果延迟之间的关联。这是一项横断面研究,于 2019 年 3 月至 2020 年 2 月在巴基斯坦三个城市地区的选定卫生机构对内部流离失所的结核病患者(IDPs)进行了登记。使用单变量和多变量逻辑回归模型来评估诊断和治疗结果的延迟。治疗开始后 30 天以上延迟的 IDP 患者,其结核病治疗结果不成功的可能性较高(调整后的比值比 AOR,2.60;95%置信区间 1.06-6.40)。此外,多变量回归分析显示,年龄在 55 至 65 岁之间的结核病患者(AOR,2.66;95%置信区间 1.00-7.07)、女性患者(AOR,2.42;95%置信区间 1.21-4.81)、就诊于非正规医疗提供者(AOR,8.81;95%置信区间 3.99-19.46)、自我用药(AOR,2.72;95%置信区间 1.37-5.37)、结核病知识匮乏(AOR,11.39;95%置信区间 3.31-39.1)和感知耻辱感(AOR,8.81;95%置信区间 3.99-19.4)之间存在统计学显著关联。治疗时间延长与 IDP 患者的不良治疗结果有关。移民和内部流离失所者更有可能因总体上被排除在社会和医疗保健服务之外而经历医疗服务中断。因此,了解提供公共卫生保健服务的障碍至关重要,特别是在预防和治疗结核病方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2988/8621790/ba8e34a9724f/ijerph-18-11984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2988/8621790/ba8e34a9724f/ijerph-18-11984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2988/8621790/ba8e34a9724f/ijerph-18-11984-g001.jpg

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