Zayet Souheil, Isnard Pierre, Bustamante Jacinta, Boutboul David, Abroug Sarra, Belfeki Nabil
Department of Infectious Diseases, Nord Franche-Comté Hospital, 90400 Trévenans, France.
Department of Pathology, Necker Hospital for Sick Children, Assistance Publique des Hopitaux de Paris (Ap-HP), 75015 Paris, France.
Pathogens. 2021 Nov 5;10(11):1438. doi: 10.3390/pathogens10111438.
Whipple's Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple's disease. The diagnosis of the bacteria was obtained from skin and inguinal lymph node biopsy (16 rDNA PCR screening and histological examination using PAS staining). was also identified on saliva and stool specimens, using specific PCR and colonic biopsies. Treatment with hydroxychloroquine and doxycycline allowed a rapid resolution of symptoms with a complete recovery.
惠普尔病是一种由普遍存在的放线菌引起的罕见的全身性传染病。我们在此报告一例罕见的皮肤肉芽肿病合并高钙血症的病例，这是惠普尔病一种不寻常的表现特征。通过皮肤和腹股沟淋巴结活检（16 rDNA PCR筛查及采用PAS染色的组织学检查）确诊了该细菌。还通过特异性PCR及结肠活检在唾液和粪便标本中鉴定出了该细菌。羟氯喹啉和强力霉素治疗使症状迅速缓解并完全康复。
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