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药物递送中的微针:进展与挑战

Microneedles in Drug Delivery: Progress and Challenges.

作者信息

Avcil Muhammet, Çelik Ayhan

机构信息

Imperial Bioscience Ltd., Mocatta House, Trafalgar Place, Brighton, East Sussex BN1 4DU, UK.

出版信息

Micromachines (Basel). 2021 Oct 28;12(11):1321. doi: 10.3390/mi12111321.

DOI:10.3390/mi12111321
PMID:34832733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8623547/
Abstract

In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals for several applications, including vaccines, drugs, and biomolecules for skin-related problems. The advantages of microneedle patch technology have been extensively evaluated in the latest literature; hence, the academic publications in this area are rising exponentially. Like all new technologies, the microneedle patch application has great potential but is not without limitations. In this review, we will discuss the possible limitations by highlighting the areas where a great deal of improvements are required. Emphasising these concerns early on should help scientists and technologists to address the matters in a timely fashion and to use their resources wisely.

摘要

近年来,一种创新的透皮给药技术因其能够为多种应用(包括疫苗、药物以及用于解决皮肤相关问题的生物分子)递送治疗剂和药妆品而备受关注。微针贴片技术的优势已在最新文献中得到广泛评估;因此,该领域的学术出版物数量呈指数级增长。与所有新技术一样,微针贴片应用具有巨大潜力,但也并非没有局限性。在本综述中,我们将通过强调需要大量改进的领域来讨论可能存在的局限性。尽早强调这些问题应有助于科学家和技术专家及时解决这些问题,并明智地利用他们的资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5628/8623547/a8e0c2a5d5b4/micromachines-12-01321-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5628/8623547/9688492808d3/micromachines-12-01321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5628/8623547/381e740c38ef/micromachines-12-01321-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5628/8623547/a8e0c2a5d5b4/micromachines-12-01321-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5628/8623547/9688492808d3/micromachines-12-01321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5628/8623547/381e740c38ef/micromachines-12-01321-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5628/8623547/a8e0c2a5d5b4/micromachines-12-01321-g003.jpg

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Nanomedicines and microneedles: a guide to their analysis and application.纳米药物和微针:分析与应用指南。
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Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial.来自一项随机I期试验的微针贴片接种季节性流感疫苗的免疫机制
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