Main Benjamin J, Maffulli Nicola, Valk Josiah A, Rodriguez Hugo C, Gupta Manu, El-Amin Saadiq F, Gupta Ashim
Department of Orthopaedic Surgery, Beaumont Hospital Farmington Hills, Farmington Hills, MI 48336, USA.
Department of Musculoskeletal Disorders, School of Medicine and Surgery, University of Salerno, 84081 Baronissi, Italy.
Pharmaceuticals (Basel). 2021 Oct 27;14(11):1090. doi: 10.3390/ph14111090.
Musculoskeletal ailments affect millions of people around the world and place a high burden on healthcare. Traditional treatment modalities are limited and do not address underlying pathologies. Mesenchymal stem cells (MSCs) have emerged as an exciting therapeutic alternative and Wharton's jelly-derived mesenchymal stem cells (WJSCs) are some of these. This review reports the clinical and functional outcomes of the applications of WJSCs in orthopedic surgery. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The studies that used culture-expanded, mesenchymal stem or stromal cells, MSCs and/or connective tissues procured from Wharton's jelly (WJ), from January 2010 to October 2021, were included. Conventional non-operative therapies and placebos were used as comparisons. Six studies that directly discussed WJSCs use in an animal model or the basic scientific testing using an injury model were identified. Five publications studied cartilage injury, three studied degenerative disc disease, one was related to osteoarthritis, and one was related to osteochondral defects. The results of these studies suggested the benefits of WJSCs in the management of these orthopedic pathologies. To adequately assess the safety and efficacy of WJSCs in orthopedic surgery, further randomized controlled clinical studies are necessary.
肌肉骨骼疾病影响着全球数百万人，给医疗保健带来了沉重负担。传统治疗方式有限，无法解决潜在的病理问题。间充质干细胞（MSCs）已成为一种令人兴奋的治疗选择，其中包括源自脐带华通氏胶的间充质干细胞（WJSCs）。本综述报告了WJSCs在骨科手术中的临床和功能结果。利用系统评价与Meta分析的首选报告项目（PRISMA）指南进行了系统评价。纳入了2010年1月至2021年10月期间使用从脐带华通氏胶（WJ）获取的培养扩增的间充质干细胞、间充质干细胞或基质细胞、MSCs和/或结缔组织的研究。将传统非手术疗法和安慰剂用作对照。确定了六项直接讨论WJSCs在动物模型中的应用或使用损伤模型进行基础科学测试的研究。五项出版物研究了软骨损伤，三项研究了椎间盘退变疾病，一项与骨关节炎有关，一项与骨软骨缺损有关。这些研究结果表明WJSCs在这些骨科疾病管理中的益处。为了充分评估WJSCs在骨科手术中的安全性和有效性，有必要进行进一步的随机对照临床研究。
