Stefańska Katarzyna, Ożegowska Katarzyna, Hutchings Greg, Popis Małgorzata, Moncrieff Lisa, Dompe Claudia, Janowicz Krzysztof, Pieńkowski Wojciech, Gutaj Paweł, Shibli Jamil A, Prado Walterson Mathias, Piotrowska-Kempisty Hanna, Mozdziak Paul, Bruska Małgorzata, Zabel Maciej, Kempisty Bartosz, Nowicki Michał
Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Department of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.
J Clin Med. 2020 Apr 12;9(4):1102. doi: 10.3390/jcm9041102.
Stem cell therapies offer a great promise for regenerative and reconstructive medicine, due to their self-renewal and differentiation capacity. Although embryonic stem cells are pluripotent, their utilization involves embryo destruction and is ethically controversial. Therefore, adult tissues that have emerged as an alternative source of stem cells and perinatal tissues, such as the umbilical cord, appear to be particularly attractive. Wharton's jelly, a gelatinous connective tissue contained in the umbilical cord, is abundant in mesenchymal stem cells (MSCs) that express CD105, CD73, CD90, Oct-4, Sox-2, and Nanog among others, and have the ability to differentiate into osteogenic, adipogenic, chondrogenic, and other lineages. Moreover, Wharton's jelly-derived MSCs (WJ-MSCs) do not express MHC-II and exhibit immunomodulatory properties, which makes them a good alternative for allogeneic and xenogeneic transplantations in cellular therapies. Therefore, umbilical cord, especially Wharton's jelly, is a promising source of mesenchymal stem cells.
干细胞疗法因其自我更新和分化能力，为再生医学和重建医学带来了巨大希望。尽管胚胎干细胞具有多能性，但其应用涉及胚胎破坏，在伦理上存在争议。因此，已成为干细胞替代来源的成体组织以及围产期组织，如脐带，似乎特别具有吸引力。华通氏胶是脐带中所含的一种凝胶状结缔组织，富含间充质干细胞（MSC），这些细胞表达CD105、CD73、CD90、Oct-4、Sox-2和Nanog等，并且具有分化为成骨、成脂、成软骨和其他谱系的能力。此外，源自华通氏胶的间充质干细胞（WJ-MSC）不表达MHC-II，并具有免疫调节特性，这使其成为细胞治疗中同种异体和异种移植的良好替代选择。因此，脐带，尤其是华通氏胶，是一种很有前景的间充质干细胞来源。
