Kikushima Wataru, Shijo Taiyo, Furuhata Yukiko, Sakurada Yoichi, Kashiwagi Kenji
Department of Ophthalmology, University of Yamanashi, Chuo 409-3898, Yamanashi, Japan.
Pharmaceuticals (Basel). 2021 Oct 28;14(11):1100. doi: 10.3390/ph14111100.
We investigated the efficacy and safety of red (670 nm) subthreshold micropulse laser (SMPL) treatment for diabetic macular edema (DME) and compared the 1-year treatment outcomes of red and yellow (577 nm) SMPL for DME. A medical chart review was performed in 43 consecutive eyes of 35 patients who underwent red or yellow SMPL treatment for DME and were followed up for 12 months. There were 26 and 17 eyes in the yellow and red SMPL groups, respectively. The mean best-corrected visual acuity (BCVA) was maintained throughout the follow-up period of 12 months in the yellow and red SMPL groups ( = 0.39, = 0.70, respectively). The central retinal thickness (CRT) measured by spectral-domain optical coherence tomography (SD-OCT) was significantly decreased at 12 months from baseline in the yellow and red SMPL groups ( = 0.047, = 0.03, respectively). Although the amount of CRT reduction in the red SMPL group was significantly greater than that in the yellow SMPL group at 8 months from baseline ( = 0.02), the significance disappeared at the final follow-up period ( = 0.44). The red SMPL maintained the BCVA in patients with center-involving DME. The mean CRT in the red SMPL group significantly decreased, and the amount of CRT reduction was equivalent to that in the yellow SMPL group.
我们研究了红色（670纳米）阈下微脉冲激光（SMPL）治疗糖尿病性黄斑水肿（DME）的疗效和安全性，并比较了红色和黄色（577纳米）SMPL治疗DME的1年治疗效果。对35例接受红色或黄色SMPL治疗DME并随访12个月的患者的43只连续眼睛进行了病历回顾。黄色和红色SMPL组分别有26只和17只眼睛。在黄色和红色SMPL组的12个月随访期内，平均最佳矫正视力（BCVA）均得以维持（分别为=0.39，=0.70）。在黄色和红色SMPL组中，通过光谱域光学相干断层扫描（SD-OCT）测量的中心视网膜厚度（CRT）在12个月时较基线水平显著降低（分别为=0.047，=0.03）。尽管在距基线8个月时，红色SMPL组的CRT降低量显著大于黄色SMPL组（=0.02），但在最终随访期该差异不再显著（=0.44）。红色SMPL可维持累及中心的DME患者的BCVA。红色SMPL组的平均CRT显著降低，且CRT降低量与黄色SMPL组相当。
