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模仿人眼调节功能的人工晶状体囊膜的特性与建模

Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes.

作者信息

Wei Huidong, Wolffsohn James S, Gomes de Oliveira Otavio, Davies Leon N

机构信息

College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK.

Rayner Intraocular Lenses Limited, Worthing BN14 8AQ, UK.

出版信息

Polymers (Basel). 2021 Nov 12;13(22):3916. doi: 10.3390/polym13223916.

Abstract

A synthetic material of silicone rubber was used to construct an artificial lens capsule (ALC) in order to replicate the biomechanical behaviour of human lens capsule. The silicone rubber was characterised by monotonic and cyclic mechanical tests to reveal its hyper-elastic behaviour under uniaxial tension and simple shear as well as the rate independence. A hyper-elastic constitutive model was calibrated by the testing data and incorporated into finite element analysis (FEA). An experimental setup to simulate eye focusing (accommodation) of ALC was performed to validate the FEA model by evaluating the shape change and reaction force. The characterisation and modelling approach provided an insight into the intrinsic behaviour of materials, addressing the inflating pressure and effective stretch of ALC under the focusing process. The proposed methodology offers a virtual testing environment mimicking human capsules for the variability of dimension and stiffness, which will facilitate the verification of new ophthalmic prototype such as accommodating intraocular lenses (AIOLs).

摘要

为了复制人晶状体囊的生物力学行为,使用了一种硅橡胶合成材料来构建人工晶状体囊(ALC)。通过单调和循环力学测试对硅橡胶进行表征,以揭示其在单轴拉伸和简单剪切下的超弹性行为以及速率无关性。通过测试数据校准了一个超弹性本构模型,并将其纳入有限元分析(FEA)。进行了一个模拟ALC眼睛聚焦(调节)的实验装置,通过评估形状变化和反作用力来验证FEA模型。表征和建模方法深入了解了材料的内在行为,解决了聚焦过程中ALC的充气压力和有效拉伸问题。所提出的方法提供了一个虚拟测试环境,可模拟人晶状体囊在尺寸和刚度方面的变化,这将有助于验证新型眼科原型,如可调节人工晶状体(AIOL)。

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