David G, Pedrigi R M, Humphrey J D
a Institute of Mathematics , University of the Philippines , Quezon City , Philippines .
b Department of Bioengineering , Imperial College London , London , UK .
Comput Methods Biomech Biomed Engin. 2017 Feb;20(3):302-307. doi: 10.1080/10255842.2016.1228907. Epub 2016 Sep 9.
Accommodation of the eyes, the mechanism that allows humans to focus their vision on near objects, naturally diminishes with age via presbyopia. People who have undergone cataract surgery, using current surgical methods and artificial lens implants, are also left without the ability to accommodate. The process of accommodation is generally well known; however the specific mechanical details have not been adequately explained due to difficulties and consequences of performing in vivo studies. Most studies have modeled the mechanics of accommodation under assumptions of a linearly elastic, isotropic, homogenous lens and lens capsule. Recent experimental and numerical studies showed that the lens capsule exhibits nonlinear elasticity and regional anisotropy. In this paper we present a numerical model of human accommodation using a membrane theory based finite element approach, incorporating recent findings on capsular properties. This study seeks to provide a novel perspective of the mechanics of accommodation. Such findings may prove significant in seeking biomedical solutions to restoring loss of visual power.
眼睛的调节功能，即人类将视力聚焦于近处物体的机制，会随着年龄增长因老花眼而自然衰退。接受过白内障手术的人，采用当前的手术方法并植入人工晶状体后，也会失去调节能力。调节过程通常广为人知；然而，由于进行体内研究存在困难和后果，具体的机械细节尚未得到充分解释。大多数研究在假设晶状体和晶状体囊为线性弹性、各向同性、均匀的情况下对调节力学进行建模。最近的实验和数值研究表明，晶状体囊表现出非线性弹性和区域各向异性。在本文中，我们使用基于膜理论的有限元方法提出了一个人类调节的数值模型，纳入了关于囊膜特性的最新研究结果。本研究旨在提供调节力学的新视角。这些发现可能在寻求恢复视力丧失的生物医学解决方案方面具有重要意义。
