Kim Gun-Jik, Lee Jae-Ho, Chae Mincheol, Lee Deok-Heon
Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea.
Department of Anatomy, Keimyung University School of Medicine, Dageu 42601, Korea.
Medicina (Kaunas). 2021 Nov 10;57(11):1223. doi: 10.3390/medicina57111223.
: Telomeric zinc finger-associated protein (TZAP) is a telomere regulation protein, previously known as ZBTB48. It binds preferentially to elongated telomeres, competing with telomeric repeat factors 1 and 2. TZAP expression may be associated with carcinogenesis, however; this study has not yet been performed in lung cancer. In this study, we examined the clinicopathological and prognostic values of TZAP expression in non-small cell lung cancer (NSCLC). Data were collected from The Cancer Genome Atlas. The clinical and prognostic values of TZAP for NSCLC were examined in adenocarcinoma (AD) and squamous cell carcinoma (SCC). TZAP expression significantly increased in NSCLC tissues compared with normal tissues. In AD, TZAP expression was lower in patients with higher T stage ( = 0.005), and was associated with lymph node stage in SCC ( = 0.005). Survival analysis showed shorter disease-free survival in AD patients with lower TZAP expression ( = 0.047). TZAP expression did not have other clinical or prognostic value for AD and SCC. : TZAP expression is a potential prognostic marker for NSCLC, especially in patients with AD.
端粒锌指相关蛋白（TZAP）是一种端粒调节蛋白，以前称为ZBTB48。它优先结合延长的端粒，与端粒重复因子1和2竞争。然而，TZAP的表达可能与致癌作用有关；这项研究尚未在肺癌中进行。在本研究中，我们检测了TZAP表达在非小细胞肺癌（NSCLC）中的临床病理和预后价值。数据来自癌症基因组图谱。在腺癌（AD）和鳞状细胞癌（SCC）中检测了TZAP对NSCLC的临床和预后价值。与正常组织相比，NSCLC组织中TZAP表达显著增加。在AD中，T分期较高的患者中TZAP表达较低（P = 0.005），并且在SCC中与淋巴结分期相关（P = 0.005）。生存分析显示，TZAP表达较低的AD患者无病生存期较短（P = 0.047）。TZAP表达对AD和SCC没有其他临床或预后价值。：TZAP表达是NSCLC的潜在预后标志物，尤其是在AD患者中。
