Saha Priyanka, Bose Subhankar, Srivastava Amit Kumar, Chaudhary Anis Ahmad, Lall Rajiv, Prasad Sahdeo
Cancer Biology & Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, WB, India.
Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSUI), Riyadh 11623, Saudi Arabia.
Molecules. 2021 Nov 10;26(22):6783. doi: 10.3390/molecules26226783.
The novel coronavirus disease (COVID-19), the reason for worldwide pandemic, has already masked around 220 countries globally. This disease is induced by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Arising environmental stress, increase in the oxidative stress level, weak immunity and lack of nutrition deteriorates the clinical status of the infected patients. Though several researches are at its peak for understanding and bringing forward effective therapeutics, yet there is no promising solution treating this disease directly. Medicinal plants and their active metabolites have always been promising in treating many clinical complications since time immemorial. Mother nature provides vivid chemical structures, which act multi-dimensionally all alone or synergistically in mitigating several diseases. Their unique antioxidant and anti-inflammatory activity with least side effects have made them more effective candidate for pharmacological studies. These medicinal plants inhibit attachment, encapsulation and replication of COVID-19 viruses by targeting various signaling molecules such as angiotensin converting enzyme-2, transmembrane serine protease 2, spike glycoprotein, main protease etc. This property is re-examined and its potency is now used to improve the existing global health crisis. This review is an attempt to focus various antiviral activities of various noteworthy medicinal plants. Moreover, its implications as prophylactic or preventive in various secondary complications including neurological, cardiovascular, acute kidney disease, liver disease are also pinpointed in the present review. This knowledge will help emphasis on the therapeutic developments for this novel coronavirus where it can be used as alone or in combination with the repositioned drugs to combat COVID-19.
新型冠状病毒病（COVID-19），这场全球大流行的起因，已经在全球约220个国家肆虐。这种疾病是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的。不断出现的环境压力、氧化应激水平的升高、免疫力低下和营养缺乏会使感染患者的临床状况恶化。尽管为了解并提出有效的治疗方法，多项研究正在全力开展，但目前仍没有直接治疗这种疾病的有效解决方案。自古以来，药用植物及其活性代谢产物在治疗许多临床并发症方面一直很有前景。大自然提供了丰富多样的化学结构，它们单独或协同发挥多维度作用，以减轻多种疾病。它们独特的抗氧化和抗炎活性以及最小的副作用，使其成为药理学研究中更有效的候选对象。这些药用植物通过靶向各种信号分子，如血管紧张素转换酶2、跨膜丝氨酸蛋白酶2、刺突糖蛋白、主要蛋白酶等，来抑制COVID-19病毒的附着、包裹和复制。这一特性正在被重新审视，其效力现在被用于改善当前全球健康危机。本综述旨在聚焦各种值得关注的药用植物的多种抗病毒活性。此外，本综述还指出了其在预防或防止包括神经、心血管、急性肾病、肝病等各种继发性并发症方面的意义。这些知识将有助于强调针对这种新型冠状病毒的治疗进展，在抗击COVID-19时，它可以单独使用或与重新定位的药物联合使用。
