Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia 52000, Morocco.
Energy, Materials and Sustainable Development (EMDD) Team-Higher School of Technology-SALE, Center for Water, Natural Resources Environment and Sustainable Development (CERNE2D), Mohammed V University in Rabat, Rabat, Morocco.
J Pharm Pharmacol. 2024 Oct 3;76(10):1239-1268. doi: 10.1093/jpp/rgae101.
The aim of the present review was to highlight natural product investigations in silico and in vitro to find plants and chemicals that inhibit or stimulate angiotensin-converting enzyme 2 (ACE-2).
The global reduction of incidents and fatalities attributable to infections with SARS-CoV-2 is one of the most public health problems. In the absence of specific therapy for coronavirus disease 2019 (COVID-19), phytocompounds generated from plant extracts may be a promising strategy worth further investigation, motivating researchers to evaluate the safety and anti-SARS-CoV-2 effectiveness of these ingredients.
To review phytochemicals in silico for anti-SARS-CoV-2 activity and to assess their safety and effectiveness in vitro and in vivo.
The present review was conducted using various scientific databases and studies on anti-SARS-CoV-2 phytochemicals were analyzed and summarized. The results obtained from the in silico screening were subjected to extraction, isolation, and purification. The in vitro studies on anti-SarcoV-2 were also included in this review. In addition, the results of this research were interpreted, analyzed, and documented on the basis of the bibliographic information obtained.
This review discusses recent research on using natural remedies to cure or prevent COVID-19 infection. The literature analysis shows that the various herbal preparations (extracts) and purified compounds can block the replication or entrance of the virus directly to carry out their anti-SARS-CoV-2 effects. It is interesting to note that certain items can prevent SARS-CoV-2 from infecting human cells by blocking the ACE-2 receptor or the serine protease TMPRRS2. Moreover, natural substances have been demonstrated to block proteins involved in the SARS-CoV-2 life cycle, such as papain- or chymotrypsin-like proteases.
The natural products may have the potential for use singly or in combination as alternative drugs to treat/prevent COVID-19 infection, including blocking or stimulating ACE-2. In addition, their structures may provide indications for the development of anti-SARS-CoV-2 drugs.
本综述的目的是强调天然产物的计算机模拟和体外研究，以发现抑制或刺激血管紧张素转换酶 2（ACE-2）的植物和化学物质。
全球范围内，与 SARS-CoV-2 感染相关的事件和死亡人数减少是最受关注的公共卫生问题之一。在没有针对 2019 年冠状病毒病（COVID-19）的特定疗法的情况下，来自植物提取物的植物化合物可能是一个值得进一步研究的有前途的策略，这促使研究人员评估这些成分的安全性和抗 SARS-CoV-2 有效性。
综述计算机模拟抗 SARS-CoV-2 活性的植物化学物质，并评估其在体外和体内的安全性和有效性。
本综述使用各种科学数据库进行，对抗 SARS-CoV-2 植物化学物质的研究进行了分析和总结。从计算机模拟筛选中获得的结果进行了提取、分离和纯化。本综述还包括抗 SARS-CoV-2 的体外研究结果。此外，根据获得的文献信息对研究结果进行解释、分析和记录。
本综述讨论了使用天然药物治疗或预防 COVID-19 感染的最新研究。文献分析表明，各种草药制剂（提取物）和纯化化合物可以通过直接阻断病毒的复制或进入来发挥其抗 SARS-CoV-2 作用。有趣的是，某些项目可以通过阻断 ACE-2 受体或丝氨酸蛋白酶 TMPRSS2 来阻止 SARS-CoV-2 感染人类细胞。此外，天然物质已被证明可以阻断 SARS-CoV-2 生命周期中涉及的蛋白质，如木瓜蛋白酶样或糜蛋白酶样蛋白酶。
天然产物可能具有单独或联合用作治疗/预防 COVID-19 感染的替代药物的潜力，包括阻断或刺激 ACE-2。此外，它们的结构可能为开发抗 SARS-CoV-2 药物提供线索。
