Valachová Katarína, Šoltés Ladislav
Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, SK-84104 Bratislava, Slovakia.
Pharmaceutics. 2021 Oct 31;13(11):1815. doi: 10.3390/pharmaceutics13111815.
In the minireview presented here, the authors discuss the evaluation of inhibitory effect of substances in the phases of initiation and propagation of high-molar-mass hyaluronan oxidative degradation. The experimental approach should be considered as original since on using a simple experimental assay it is possible to prove both the so-called "preventive" and "chain-breaking" antioxidant activity of investigated water-soluble endo- or exogenous substances.
在本文呈现的微型综述中,作者讨论了在高分子量透明质酸氧化降解的引发和传播阶段对物质抑制作用的评估。该实验方法应被视为原创,因为通过使用一种简单的实验测定法,有可能证明所研究的水溶性内源或外源物质的所谓“预防”和“链断裂”抗氧化活性。