Etayash Hashem, Hancock Robert E W
Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, 2259 Lower Mall Research Station, Vancouver, BC V6T 1Z4, Canada.
Pharmaceutics. 2021 Nov 1;13(11):1820. doi: 10.3390/pharmaceutics13111820.
Amphiphilic antimicrobial polymers have attracted considerable interest as structural mimics of host defense peptides (HDPs) that provide a broad spectrum of activity and do not induce bacterial-drug resistance. Likewise, surface engineered polymeric-brush-tethered HDP is considered a promising coating strategy that prevents infections and endows implantable materials and medical devices with antifouling and antibacterial properties. While each strategy takes a different approach, both aim to circumvent limitations of HDPs, enhance physicochemical properties, therapeutic performance, and enable solutions to unmet therapeutic needs. In this review, we discuss the recent advances in each approach, spotlight the fundamental principles, describe current developments with examples, discuss benefits and limitations, and highlight potential success. The review intends to summarize our knowledge in this research area and stimulate further work on antimicrobial polymers and functionalized polymeric biomaterials as strategies to fight infectious diseases.
两亲性抗菌聚合物作为宿主防御肽（HDPs）的结构模拟物引起了广泛关注，它们具有广谱活性且不会诱导细菌耐药性。同样，表面工程化的聚合物刷连接的HDP被认为是一种有前景的涂层策略，可防止感染并赋予可植入材料和医疗器械防污和抗菌性能。虽然每种策略采用不同的方法，但两者都旨在规避HDPs的局限性，增强物理化学性质、治疗性能，并为未满足的治疗需求提供解决方案。在本综述中，我们讨论了每种方法的最新进展，突出基本原理，举例描述当前的发展情况，讨论其优点和局限性，并强调潜在的成功之处。本综述旨在总结我们在该研究领域的知识，并激发对抗菌聚合物和功能化聚合物生物材料作为对抗传染病策略的进一步研究。
