Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Nat Rev Microbiol. 2021 Dec;19(12):786-797. doi: 10.1038/s41579-021-00585-w. Epub 2021 Jun 28.
Host defence peptides (HDPs) are integral components of innate immunity across all living organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells (referred to as antimicrobial peptides), and exhibit antibiofilm (referred to as antibiofilm peptides), antiviral, antifungal and host-directed immunomodulatory activities. In this Review, we discuss how the complex functional attributes of HDPs provide many opportunities for the development of antimicrobial therapeutics, focusing particularly on their emerging antibiofilm properties. The mechanisms of action of antibiofilm peptides are compared and contrasted with those of antimicrobial peptides. Furthermore, obstacles for the practical translation of candidate peptides into therapeutics and the potential solutions are discussed. Critically, HDPs have the value-added assets of complex functional attributes, particularly antibiofilm and anti-inflammatory activities and their synergy with conventional antibiotics.
宿主防御肽（HDPs）是所有生物体固有免疫的重要组成部分。这些肽可以发挥直接的抗菌作用，靶向浮游细胞（称为抗菌肽），并具有抗生物膜（称为抗生物膜肽）、抗病毒、抗真菌和宿主导向的免疫调节活性。在这篇综述中，我们讨论了 HDPs 的复杂功能特性如何为抗菌治疗药物的开发提供了许多机会，特别关注它们新出现的抗生物膜特性。抗菌肽的作用机制与抗生物膜肽的作用机制进行了比较和对比。此外，还讨论了将候选肽转化为治疗药物的实际翻译的障碍以及潜在的解决方案。至关重要的是，HDPs 具有复杂功能属性的附加值资产，特别是抗生物膜和抗炎活性以及它们与传统抗生素的协同作用。
