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通过纳米颗粒形成和共处理制备壳聚糖与高岭土复合材料作为新型片剂辅料的颗粒工程

Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing.

作者信息

Yarangsee Chonwipa, Wattanaarsakit Phanphen, Sirithunyalug Jakkapan, Leesawat Phuriwat

机构信息

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

出版信息

Pharmaceutics. 2021 Nov 3;13(11):1844. doi: 10.3390/pharmaceutics13111844.

DOI:10.3390/pharmaceutics13111844
PMID:34834259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8618914/
Abstract

Chitosan is not a common excipient for direct compression due to poor flowability and inadequate compressibility. Co-processing of chitosan and kaolin is a challenging method to overcome the limitations of the individual excipients. The purpose of the present study was to develop co-processed chitosan-kaolin by the spray drying technique (rotary atomizer spray dryer) and to characterize the excipient properties. The formation of chitosan nanoparticles was the major factor for desirable tablet hardness. The ratio of chitosan/tripolyphosphate of 10:1 and 20:1 had a significant effect on hardness. The successful development of co-processed chitosan-kaolin as a novel tablet excipient was obtained from a feed formulation composed of chitosan and kaolin at a ratio of 55:45 and the optimum chitosan/tripolyphosphate ratio of 20:1. Co-processing altered the physical properties of co-processed chitosan-kaolin in such a way that it enhanced the flowability and tableting performance compared to the physical mixture.

摘要

由于流动性差和可压性不足，壳聚糖不是直接压片常用的辅料。壳聚糖与高岭土的共处理是一种克服单一辅料局限性的具有挑战性的方法。本研究的目的是通过喷雾干燥技术（旋转雾化器喷雾干燥器）制备共处理的壳聚糖 - 高岭土，并对辅料特性进行表征。壳聚糖纳米颗粒的形成是获得理想片剂硬度的主要因素。壳聚糖/三聚磷酸钠比例为10:1和20:1对硬度有显著影响。由壳聚糖和高岭土按55:45比例组成的进料配方以及20:1的最佳壳聚糖/三聚磷酸钠比例成功开发出了共处理的壳聚糖 - 高岭土作为新型片剂辅料。共处理改变了共处理的壳聚糖 - 高岭土的物理性质，使其与物理混合物相比，流动性和压片性能得到了增强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/b977a369924d/pharmaceutics-13-01844-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/e52e8212fc66/pharmaceutics-13-01844-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/c1c36d5ab9ce/pharmaceutics-13-01844-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/32752d0f833d/pharmaceutics-13-01844-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/f08c4ff2e71f/pharmaceutics-13-01844-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/0133e76d2e99/pharmaceutics-13-01844-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/28767603b893/pharmaceutics-13-01844-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/33636e9f3422/pharmaceutics-13-01844-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/b977a369924d/pharmaceutics-13-01844-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/e52e8212fc66/pharmaceutics-13-01844-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/c1c36d5ab9ce/pharmaceutics-13-01844-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/32752d0f833d/pharmaceutics-13-01844-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/f08c4ff2e71f/pharmaceutics-13-01844-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/0133e76d2e99/pharmaceutics-13-01844-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/28767603b893/pharmaceutics-13-01844-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/33636e9f3422/pharmaceutics-13-01844-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/8618914/b977a369924d/pharmaceutics-13-01844-g008.jpg

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本文引用的文献

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