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用于增强癌症光动力治疗应用的生物相容性纳米载体

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications.

作者信息

Dhilip Kumar Sathish Sundar, Abrahamse Heidi

机构信息

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg 2028, South Africa.

出版信息

Pharmaceutics. 2021 Nov 15;13(11):1933. doi: 10.3390/pharmaceutics13111933.

Abstract

In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the side effects of anticancer drugs. Biocompatible and biodegradable properties have been essential for using a novel material as a carrier molecule in drug delivery applications. Biocompatible nanocarriers are easy to synthesize, and their surface chemistry often enables them to load different types of photosensitizers (PS) to use targeted photodynamic therapy (PDT) for cancer treatment. This review article explores recent studies on the use of different biocompatible nanocarriers, their potential applications in PDT, including PS-loaded biocompatible nanocarriers, and the effective targeting therapy of PS-loaded biocompatible nanocarriers in PDT for cancer treatment. Furthermore, the review briefly recaps the global clinical trials of PDT and its applications in cancer treatment.

摘要

近年来,纳米技术在药物递送中的作用变得越来越重要,并且该研究领域对癌症治疗具有许多潜在益处,特别是在实现癌细胞靶向和减少抗癌药物的副作用方面。生物相容性和可生物降解性对于在药物递送应用中使用新型材料作为载体分子至关重要。生物相容性纳米载体易于合成,并且它们的表面化学性质通常使它们能够负载不同类型的光敏剂(PS),以使用靶向光动力疗法(PDT)进行癌症治疗。这篇综述文章探讨了关于使用不同生物相容性纳米载体的最新研究、它们在PDT中的潜在应用,包括负载PS的生物相容性纳米载体,以及负载PS的生物相容性纳米载体在PDT中用于癌症治疗的有效靶向治疗。此外,该综述简要回顾了PDT的全球临床试验及其在癌症治疗中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7450/8624654/48e48365b7e9/pharmaceutics-13-01933-g001.jpg

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