Department of Pharmaceutical Science & Technology, Donghua University, Shanghai 201620, China.
Department of Pharmacy, Huadong Hospital, Fudan University, Shanghai 200040, China.
Nanomedicine (Lond). 2024;19(18-20):1643-1658. doi: 10.1080/17435889.2024.2370226. Epub 2024 Jul 16.
A study of the enhancement of photodynamic activities of pyropheophorbide-a using PG-Ag-PPa nanoconjugates. The nanoconjugates were formulated from silver nanoparticles and PPa via amide linkage, then characterized, and their photodynamic activities were examined. The nanoconjugates displayed a higher rate of reactive oxygen species generation, commendable cellular uptake by Eca-109 cancer cells, higher photocytotoxicity toward the cancer cells and better bio-safety. They revealed strong antibacterial activity against following internal reactive oxygen species generation and membrane disintegration. The anticancer studies confirmed higher cytotoxicity of the nanoconjugates toward cancer cells and better safety than PPa.: Therefore, PG-Ag-PPa nanoconjugates could be considered potential nano photosensitizers for photodynamic therapy of tumors and bacterial infection with good bio-safety.
用 PG-Ag-PPa 纳米复合物增强焦脱镁叶绿酸-a 的光动力活性的研究。纳米复合物是通过酰胺键由银纳米粒子和 PPa 形成的，然后对其进行了表征，并研究了它们的光动力活性。纳米复合物显示出更高的活性氧生成率、令人称道的 Eca-109 癌细胞摄取、对癌细胞更高的光细胞毒性和更好的生物安全性。它们在内部活性氧生成和膜崩解后显示出很强的抗菌活性。抗癌研究证实，与 PPa 相比，纳米复合物对癌细胞的细胞毒性更高，安全性更好。因此，PG-Ag-PPa 纳米复合物可被认为是肿瘤光动力治疗和具有良好生物安全性的细菌感染的潜在纳米光敏剂。
