• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

乌克兰 2015/16 流感季严重急性呼吸道感染患者中分离的大流行性 H1N1 流感病毒的基因型变异体。

Genotypic Variants of Pandemic H1N1 Influenza A Viruses Isolated from Severe Acute Respiratory Infections in Ukraine during the 2015/16 Influenza Season.

机构信息

Educational Scientific Centre "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.

Gromashevsky L.V. Institute of Epidemiology and Infectious Diseases, National Academy of Medical Sciences of Ukraine, 03680 Kyiv, Ukraine.

出版信息

Viruses. 2021 Oct 21;13(11):2125. doi: 10.3390/v13112125.

DOI:10.3390/v13112125
PMID:34834932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8619959/
Abstract

Human type A influenza viruses A(H1N1)pdm09 have caused seasonal epidemics of influenza since the 2009-2010 pandemic. A(H1N1)pdm09 viruses had a leading role in the severe epidemic season of 2015/16 in the Northern Hemisphere and caused a high incidence of acute respiratory infection (ARI) in Ukraine. Serious complications of influenza-associated severe ARI (SARI) were observed in the very young and individuals at increased risk, and 391 fatal cases occurred in the 2015/16 epidemic season. We analyzed the genetic changes in the genomes of A(H1N1)pdm09 influenza viruses isolated from SARI cases in Ukraine during the 2015/16 season. The viral hemagglutinin (HA) fell in H1 group 6B.1 for all but four isolates, with known mutations affecting glycosylation, the Sa antigenic site (S162N in all 6B.1 isolates), or virulence (D222G/N in two isolates). Other mutations occurred in antigenic site Ca (A141P and S236P), and a subgroup of four strains were in group 6B.2, with potential alterations to antigenicity in A(H1N1)pdm09 viruses circulating in 2015/16 in Ukraine. A cluster of Ukrainian isolates exhibited novel D2E and N48S mutations in the RNA binding domain, and E125D in the effector domain, of immune evasion nonstructural protein 1 (NS1). The diverse spectrum of amino-acid substitutions in HA, NS1, and other viral proteins including nucleoprotein (NP) and the polymerase complex suggested the concurrent circulation of multiple lineages of A(H1N1)pdm09 influenza viruses in the human population in Ukraine, a country with low vaccination coverage, complicating public health measures against influenza.

摘要

自 2009-2010 年大流行以来，人类 A 型流感病毒 A(H1N1)pdm09 已导致季节性流感流行。A(H1N1)pdm09 病毒在 2015/16 年北半球严重流行季节中起主导作用，并在乌克兰导致急性呼吸道感染（ARI）高发。在非常年幼和高风险人群中观察到与流感相关的严重急性呼吸道感染（SARI）的严重并发症，在 2015/16 流行季节发生了 391 例死亡病例。我们分析了 2015/16 年乌克兰 SARI 病例中分离的 A(H1N1)pdm09 流感病毒基因组的遗传变化。所有病毒血凝素（HA）除了 4 株外均属于 H1 组 6B.1，具有已知的影响糖基化、Sa 抗原表位（所有 6B.1 株中的 S162N）或毒力（2 株中的 D222G/N）的突变。其他突变发生在抗原表位 Ca（A141P 和 S236P），4 株属于亚组 6B.2，与 2015/16 年乌克兰流行的 A(H1N1)pdm09 病毒的抗原性可能发生改变。一组乌克兰分离株在免疫逃避非结构蛋白 1（NS1）的 RNA 结合域中表现出新型 D2E 和 N48S 突变，以及效应结构域中的 E125D。HA、NS1 和其他病毒蛋白（包括核蛋白（NP）和聚合酶复合物）的氨基酸替换的多样化谱表明，在乌克兰这个疫苗接种率较低的国家，A(H1N1)pdm09 流感病毒的多个谱系同时在人群中循环，这使得针对流感的公共卫生措施变得复杂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/bd542536bb32/viruses-13-02125-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/7bd91feb2c98/viruses-13-02125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/604b4f8b3185/viruses-13-02125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/e1b85b2cd22a/viruses-13-02125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/80218de7b4c6/viruses-13-02125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/2c4ecfb880d2/viruses-13-02125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/22efc1baf217/viruses-13-02125-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/d4931b50cf21/viruses-13-02125-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/92cca23c4e24/viruses-13-02125-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/3cf186a4bd00/viruses-13-02125-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/1e6c175d5fd8/viruses-13-02125-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/d369fcb454d9/viruses-13-02125-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/bd542536bb32/viruses-13-02125-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/7bd91feb2c98/viruses-13-02125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/604b4f8b3185/viruses-13-02125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/e1b85b2cd22a/viruses-13-02125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/80218de7b4c6/viruses-13-02125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/2c4ecfb880d2/viruses-13-02125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/22efc1baf217/viruses-13-02125-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/d4931b50cf21/viruses-13-02125-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/92cca23c4e24/viruses-13-02125-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/3cf186a4bd00/viruses-13-02125-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/1e6c175d5fd8/viruses-13-02125-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/d369fcb454d9/viruses-13-02125-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481f/8619959/bd542536bb32/viruses-13-02125-g012.jpg

相似文献

1
Genotypic Variants of Pandemic H1N1 Influenza A Viruses Isolated from Severe Acute Respiratory Infections in Ukraine during the 2015/16 Influenza Season.乌克兰 2015/16 流感季严重急性呼吸道感染患者中分离的大流行性 H1N1 流感病毒的基因型变异体。
Viruses. 2021 Oct 21;13(11):2125. doi: 10.3390/v13112125.
2
Evolution of the hemagglutinin expressed by human influenza A(H1N1)pdm09 and A(H3N2) viruses circulating between 2008-2009 and 2013-2014 in Germany.2008 - 2009年至2013 - 2014年期间在德国传播的甲型H1N1pdm09流感病毒和甲型H3N2流感病毒所表达血凝素的演变情况。
Int J Med Microbiol. 2015 Oct;305(7):762-75. doi: 10.1016/j.ijmm.2015.08.030. Epub 2015 Aug 21.
3
Molecular characterization of the influenza A(H1N1)pdm09 isolates collected in the 2015-2016 season and comparison of HA mutations detected in Turkey since 2009.2015-2016 年季节采集的甲型 H1N1pdm09 流感病毒分离株的分子特征及 2009 年以来土耳其检测到的 HA 突变比较。
J Med Virol. 2019 Dec;91(12):2074-2082. doi: 10.1002/jmv.25565. Epub 2019 Aug 20.
4
Molecular epidemiology of the hemagglutinin gene of prevalent influenza virus A/H1N1/pdm09 among patient in Iran.伊朗流行的甲型 H1N1/pdm09 流感病毒血凝素基因的分子流行病学研究。
Virus Res. 2019 Jan 2;259:38-45. doi: 10.1016/j.virusres.2018.10.001. Epub 2018 Oct 15.
5
Antigenic and genetic characterization of influenza viruses circulating in Bulgaria during the 2015/2016 season.2015/2016年流行于保加利亚的流感病毒的抗原性和基因特征
Infect Genet Evol. 2017 Apr;49:241-250. doi: 10.1016/j.meegid.2017.01.027. Epub 2017 Jan 27.
6
Phylogenetic analyses of influenza A (H1N1)pdm09 hemagglutinin gene during and after the pandemic event in Brazil.巴西甲型（H1N1）pdm09流感大流行期间及之后血凝素基因的系统发育分析。
Infect Genet Evol. 2015 Dec;36:147-155. doi: 10.1016/j.meegid.2015.09.007. Epub 2015 Sep 11.
7
Predominance of influenza A(H3N2) viruses during the 2016/2017 season in Bulgaria.2016/2017年度保加利亚流感季节甲型（H3N2）病毒占主导地位。
J Med Microbiol. 2018 Feb;67(2):228-239. doi: 10.1099/jmm.0.000668. Epub 2018 Jan 3.
8
Molecular epidemiology and evolution of A(H1N1)pdm09 and H3N2 virus during winter 2012-2013 in Beijing, China.2012 - 2013年冬季中国北京甲型H1N1流感大流行病毒和H3N2病毒的分子流行病学及进化情况
Infect Genet Evol. 2014 Aug;26:228-40. doi: 10.1016/j.meegid.2014.05.034. Epub 2014 Jun 7.
9
Genetic diversity of influenza A viruses circulating in Bulgaria during the 2018-2019 winter season.保加利亚 2018-2019 年冬季流行的甲型流感病毒的遗传多样性。
J Med Microbiol. 2020 Jul;69(7):986-998. doi: 10.1099/jmm.0.001198.
10
Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.2013/14流感季节期间，全球流感医院监测网络圣彼得堡和巴伦西亚站点流感相关住院患者的流感病毒基因特征分析。
J Clin Virol. 2016 Nov;84:32-38. doi: 10.1016/j.jcv.2016.09.006. Epub 2016 Sep 28.

引用本文的文献

1
Comprehensive molecular epidemiology of influenza viruses in Brazil: insights from a nationwide analysis.巴西流感病毒的综合分子流行病学：来自全国性分析的见解
Virus Evol. 2024 Nov 23;11(1):veae102. doi: 10.1093/ve/veae102. eCollection 2025.
2
Identification and analysis of B cell epitopes of hemagglutinin of H1N1 influenza virus.鉴定和分析 H1N1 流感病毒血凝素的 B 细胞表位。
Arch Microbiol. 2022 Sep 2;204(9):594. doi: 10.1007/s00203-022-03133-z.

本文引用的文献

1
Differential disease severity and whole-genome sequence analysis for human influenza A/H1N1pdm virus in 2015-2016 influenza season.2015 - 2016流感季节甲型H1N1pdm人源流感病毒的疾病严重程度差异及全基因组序列分析
Virus Evol. 2021 May 18;7(1):veab044. doi: 10.1093/ve/veab044. eCollection 2021 Jan.
2
Neutralizing Antibodies Targeting the Conserved Stem Region of Influenza Hemagglutinin.靶向流感血凝素保守茎区的中和抗体。
Vaccines (Basel). 2020 Jul 12;8(3):382. doi: 10.3390/vaccines8030382.
3
Antigenic characterization of novel H1 influenza A viruses in swine.
新型 H1 流感 A 病毒在猪群中的抗原特征。
Sci Rep. 2020 Mar 11;10(1):4510. doi: 10.1038/s41598-020-61315-5.
4
Assessing antigenic drift and phylogeny of influenza A (H1N1) pdm09 virus in Kenya using HA1 sub-unit of the hemagglutinin gene.利用血凝素基因的 HA1 亚单位评估肯尼亚的甲型流感（H1N1）pdm09 病毒的抗原漂移和系统进化。
PLoS One. 2020 Feb 11;15(2):e0228029. doi: 10.1371/journal.pone.0228029. eCollection 2020.
5
Impaired Vaccine-Induced Antibody Response Against Clade 6B H1N1 Viruses in Individuals Before Viral Emergence.在6B分支H1N1病毒出现之前，个体对其疫苗诱导的抗体反应受损。
Open Forum Infect Dis. 2020 Jan 11;7(1):ofz513. doi: 10.1093/ofid/ofz513. eCollection 2020 Jan.
6
Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.甲型流感病毒血凝素突变与使用神经氨酸酶抑制剂相关，与抗流感抗体的抑制作用降低相关。
Virol J. 2019 Nov 29;16(1):149. doi: 10.1186/s12985-019-1258-x.
7
Antigenic Site Variation in the Hemagglutinin of Pandemic Influenza A(H1N1)pdm09 Viruses between 2009-2017 in Ukraine.2009 - 2017年乌克兰甲型H1N1pdm09大流行性流感病毒血凝素的抗原位点变异
Pathogens. 2019 Oct 18;8(4):194. doi: 10.3390/pathogens8040194.
8
Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China.2013 年至 2015 年期间中国广东猪源流感 A 病毒的持续进化。
PLoS One. 2019 Jul 19;14(7):e0217607. doi: 10.1371/journal.pone.0217607. eCollection 2019.
9
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.甲型流感病毒 NS1 和 PA-X 蛋白对固有免疫反应的调节。
Viruses. 2018 Dec 12;10(12):708. doi: 10.3390/v10120708.
10
Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks.2013/2014 年和 2015/2016 年以 clade 6B/6B.1/6B.2 为主的甲型 H1N1 流感大流行期间实验室确诊的流感患者的临床特征。
Sci Rep. 2018 Oct 23;8(1):15636. doi: 10.1038/s41598-018-34077-4.