AUSL-IRCCS di Reggio Emilia, Servizio di Prevenzione e Sicurezza Negli Ambienti di Lavoro (SPSAL), Local Health Unit of Reggio Emilia, Via Amendola n.2, I-42122 Reggio Emilia, Italy.
AUSL-IRCCS di Reggio Emilia, Laboratorio Analisi Chimico Cliniche e Microbiologiche, Ospedale Civile di Guastalla, I-42016 Guastalla, Italy.
Viruses. 2021 Oct 25;13(11):2150. doi: 10.3390/v13112150.
Hantaviruses are zoonotic pathogens that can cause serious human disorders, including hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. As the main risk factor for human infections is the interaction with rodents, occupational groups such as farmers and forestry workers are reportedly at high risk, but no summary evidence has been collected to date. Therefore, we searched two different databases (PubMed and EMBASE), focusing on studies reporting the prevalence of hantaviruses in farmers and forestry workers. Data were extracted using a standardized assessment form, and results of such analyses were systematically reported, summarized and compared. We identified a total of 42 articles, including a total of 28 estimates on farmers, and 22 on forestry workers, with a total workforce of 15,043 cases (821 positive cases, 5.5%). A pooled seroprevalence of 3.7% (95% confidence interval [95% CI] 2.2-6.2) was identified in farmers, compared to 3.8% (95% CI 2.6-5.7) in forestry workers. Compared to the reference population, an increased occurrence was reported for both occupational groups (odds ratio [OR] 1.875, 95% CI 1.438-2.445 and OR 2.892, 95% CI 2.079-4.023 for farmers and forestry workers, respectively). In summary, our analyses stress the actual occurrence of hantaviruses in selected occupational groups. Improved understanding of appropriate preventive measures, as well as further studies on hantavirus infection rates in reservoir host species (rodents, shrews, and bats) and virus transmission to humans, is needed to prevent future outbreaks.
汉坦病毒是一种人畜共患的病原体，可导致严重的人类疾病，包括肾综合征出血热和汉坦病毒心肺综合征。由于人类感染的主要危险因素是与啮齿动物的相互作用，据报道，农民和林业工人等职业群体面临较高的感染风险，但迄今为止尚未收集到汇总证据。因此，我们在两个不同的数据库（PubMed 和 EMBASE）中搜索了报告农民和林业工人中汉坦病毒流行情况的研究。使用标准化评估表提取数据，并系统地报告、总结和比较此类分析的结果。我们共确定了 42 篇文章，其中包括 28 篇关于农民的文章和 22 篇关于林业工人的文章，总劳动力为 15043 例（821 例阳性病例，5.5%）。在农民中，总血清阳性率为 3.7%（95%置信区间 [95%CI] 2.2-6.2），而在林业工人中为 3.8%（95%CI 2.6-5.7）。与参照人群相比，两个职业群体的发生率均有所增加（农民的比值比 [OR] 1.875，95%CI 1.438-2.445；林业工人的 OR 2.892，95%CI 2.079-4.023）。总之，我们的分析强调了选定职业群体中汉坦病毒的实际发生情况。需要更好地了解适当的预防措施，并进一步研究宿主动物（啮齿动物、鼩鼱和蝙蝠）中的汉坦病毒感染率以及病毒向人类的传播，以预防未来的疫情爆发。
