Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P.R. China.
Dali University, Dali, P.R. China.
PLoS Negl Trop Dis. 2024 Aug 29;18(8):e0012437. doi: 10.1371/journal.pntd.0012437. eCollection 2024 Aug.
Hemorrhagic fever with renal syndrome caused by hantaviruses has long been a serious public health issue in Yunnan Province. Hantaviruses exhibit a high extent of biodiversity in their natural hosts, particularly in mammalian hosts. This study was conducted to screen for hantaviruses in bats and rodents in Yunnan Province and elucidate their genetic characteristics and possible zoonotic disease risk. Hantaviruses were detected in 202 bats and 372 rodents with the positive rates 27.49% and 1.25% respectively. A novel lineage (named Lineage 10) of the Seoul virus (SEOV) from rodents and the geographic clustering of hantavirus in bats were identified using phylogenetic analyses of the full-length M- and S-segments. Our study suggest a high cross-species transmissibility of hantaviruses in bats and existence of a new lineage of SEOV in rodents differing significantly from other SEOVs. These results provide data to support the prevention and control of hantavirus-associated diseases in Yunnan Province.
汉坦病毒引起的肾综合征出血热一直是云南省严重的公共卫生问题。汉坦病毒在其自然宿主中表现出高度的生物多样性，尤其是在哺乳动物宿主中。本研究旨在筛选云南省蝙蝠和啮齿动物中的汉坦病毒，并阐明其遗传特征和可能的人畜共患病风险。在 202 只蝙蝠和 372 只啮齿动物中检测到汉坦病毒，阳性率分别为 27.49%和 1.25%。通过对全长 M 片段和 S 片段的系统进化分析，从啮齿动物中鉴定出一种新的汉城病毒（SEO）谱系（命名为谱系 10），并发现蝙蝠中汉坦病毒的地理聚类。我们的研究表明，汉坦病毒在蝙蝠中有很高的种间传播能力，并且在啮齿动物中存在一种与其他 SEO 病毒显著不同的新型 SEOV 谱系。这些结果为云南省汉坦病毒相关疾病的预防和控制提供了数据支持。
