新冠肺炎患者住院相关的精神健康和物质使用情况：一项基于人群的队列研究。
Mental Health and Substance Use Associated with Hospitalization among People with COVID-19: A Population-Based Cohort Study.
机构信息
British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
出版信息
Viruses. 2021 Oct 31;13(11):2196. doi: 10.3390/v13112196.
This study identified factors associated with hospital admission among people with laboratory-diagnosed COVID-19 cases in British Columbia. The study used data from the BC COVID-19 Cohort, which integrates data on all COVID-19 cases with data on hospitalizations, medical visits, emergency room visits, prescription drugs, chronic conditions and deaths. The analysis included all laboratory-diagnosed COVID-19 cases in British Columbia to 15 January 2021. We evaluated factors associated with hospital admission using multivariable Poisson regression analysis with robust error variance. Of the 56,874 COVID-19 cases included in the analysis, 2298 were hospitalized. Factors associated with increased hospitalization risk were as follows: male sex (adjusted risk ratio (aRR) = 1.27; 95% CI = 1.17-1.37), older age (-trend < 0.0001 across age groups increasing hospitalization risk with increasing age [aRR 30-39 years = 3.06; 95% CI = 2.32-4.03, to aRR 80+ years = 43.68; 95% CI = 33.41-57.10 compared to 20-29 years-old]), asthma (aRR = 1.15; 95% CI = 1.04-1.26), cancer (aRR = 1.19; 95% CI = 1.09-1.29), chronic kidney disease (aRR = 1.32; 95% CI = 1.19-1.47), diabetes (treated without insulin aRR = 1.13; 95% CI = 1.03-1.25, requiring insulin aRR = 5.05; 95% CI = 4.43-5.76), hypertension (aRR = 1.19; 95% CI = 1.08-1.31), injection drug use (aRR = 2.51; 95% CI = 2.14-2.95), intellectual and developmental disabilities (aRR = 1.67; 95% CI = 1.05-2.66), problematic alcohol use (aRR = 1.63; 95% CI = 1.43-1.85), immunosuppression (aRR = 1.29; 95% CI = 1.09-1.53), and schizophrenia and psychotic disorders (aRR = 1.49; 95% CI = 1.23-1.82). In an analysis restricted to women of reproductive age, pregnancy (aRR = 2.69; 95% CI = 1.42-5.07) was associated with increased risk of hospital admission. Older age, male sex, substance use, intellectual and developmental disability, chronic comorbidities, and pregnancy increase the risk of COVID-19-related hospitalization.
本研究确定了不列颠哥伦比亚省经实验室诊断的 COVID-19 病例住院相关的因素。该研究使用了不列颠哥伦比亚省 COVID-19 队列的数据，该队列整合了所有 COVID-19 病例的数据以及住院、就诊、急诊就诊、处方药、慢性病和死亡的数据。分析包括截至 2021 年 1 月 15 日不列颠哥伦比亚省所有经实验室诊断的 COVID-19 病例。我们使用多变量泊松回归分析和稳健误差方差评估了与住院相关的因素。在分析中包括的 56874 例 COVID-19 病例中，有 2298 例住院。与住院风险增加相关的因素如下：男性（调整后的风险比（aRR）= 1.27；95%置信区间（CI）= 1.17-1.37），年龄较大（趋势<0.0001，年龄组之间的住院风险随着年龄的增长而增加[aRR 30-39 岁=3.06；95%CI=2.32-4.03，aRR 80+岁=43.68；95%CI=33.41-57.10，与 20-29 岁相比]），哮喘（aRR=1.15；95%CI=1.04-1.26），癌症（aRR=1.19；95%CI=1.09-1.29），慢性肾脏病（aRR=1.32；95%CI=1.19-1.47），糖尿病（未用胰岛素治疗的 aRR=1.13；95%CI=1.03-1.25，需要胰岛素的 aRR=5.05；95%CI=4.43-5.76），高血压（aRR=1.19；95%CI=1.08-1.31），注射吸毒（aRR=2.51；95%CI=2.14-2.95），智力和发育障碍（aRR=1.67；95%CI=1.05-2.66），有问题的酒精使用（aRR=1.63；95%CI=1.43-1.85），免疫抑制（aRR=1.29；95%CI=1.09-1.53）和精神分裂症和精神病障碍（aRR=1.49；95%CI=1.23-1.82）。在仅针对育龄妇女的分析中，怀孕（aRR=2.69；95%CI=1.42-5.07）与住院风险增加相关。年龄较大、男性、药物使用、智力和发育障碍、慢性合并症以及怀孕会增加与 COVID-19 相关的住院风险。
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