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漆酶催化的具有磺胺或砜结构的抗生素衍生化反应

Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures.

作者信息

Mikolasch Annett, Hahn Veronika

机构信息

Institute for Microbiology, University of Greifswald, Felix-Hausdorff-Str. 8, 17489 Greifswald, Germany.

Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Felix-Hausdorff-Str. 8, 17489 Greifswald, Germany.

出版信息

Microorganisms. 2021 Oct 21;9(11):2199. doi: 10.3390/microorganisms9112199.

DOI:10.3390/microorganisms9112199
PMID:34835324
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8620746/
Abstract

spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the -hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of species, including multidrug-resistant strains.

摘要

特定漆酶（EC 1.10.3.2.）介导具有磺酰胺或砜结构的抗生素与2,5 - 二羟基苯衍生物的氧化偶联反应，形成新的异二聚体和异三聚体。这些异分子杂化产物是由对苯二酚与磺酰胺或砜类抗生素的伯氨基进行核胺化反应形成的，并且它们在体外抑制了包括多重耐药菌株在内的多种物种的生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b468/8620746/61f74587e26d/microorganisms-09-02199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b468/8620746/edc1b11525fd/microorganisms-09-02199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b468/8620746/1b28def9dda2/microorganisms-09-02199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b468/8620746/61f74587e26d/microorganisms-09-02199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b468/8620746/edc1b11525fd/microorganisms-09-02199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b468/8620746/1b28def9dda2/microorganisms-09-02199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b468/8620746/61f74587e26d/microorganisms-09-02199-g003.jpg

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Eng Life Sci. 2019 Sep 30;19(11):805-814. doi: 10.1002/elsc.201900118. eCollection 2019 Nov.
3
Ring-Closure Mechanisms Mediated by Laccase to Synthesize Phenothiazines, Phenoxazines, and Phenazines.
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